吡咯烷-2,3,5-三酮的一种高效合成法  

An efficient method for preparation of pyrrolidine-2,3,5-triones

作　　者：陈莉[1] 张勇[1] 刘群[2] 

机构地区：[1]山西大学化学化工学院,山西太原030006 [2]东北师范大学化学学院,吉林长春130024

出　　处：《化学研究与应用》2014年第3期464-468,共5页Chemical Research and Application

基　　金：山西大学博士科研启动经费项目(011251901002)资助

摘　　要：报道了一种高效合成吡咯烷-2,3,5-三酮的新方法,即以二氯甲烷为溶剂,无任何催化剂存在下,α-胺/氨甲酰基二硫缩烯酮即可与草酰氯反应,以很高的产率生成吡咯烷-2,3,5-三酮。该方法反应条件温和,反应时间短,产率高,为吡咯烷-2,3,5-三酮的合成提供了新方法。In this paper,we described a novel efficient method for preparation of pyrrolidine-2,3,5-triones via the reaction betweenα-acylamino ketene-（S,S）-acetals and oxalyl chloride in CH2Cl2 without any catalyst. Pyrrolidine-2,3,5-triones were synthesized in high yields. The reaction conditions were optimized,and a tentative reaction mechanism was proposed. The simple procedure,mild condition and high yield make this protocol most attractive for synthesis of pyrrolidine-2,3,5-triones.

关 键 词：α-胺氨甲酰基二硫缩烯酮 草酰氯 吡咯烷-2  3  5-三酮 

分 类 号：O623[理学—有机化学]