骨碎补对链霉素耳毒性解毒作用的实验研究  

Gusuibu Attenuates the Ototoxicity by Streptomycin

作　　者：戴小牛[1] 童素琴[1] 贾淑萍[1] 陶艳梅 

机构地区：[1]南京铁道医学院生理学教研室,江苏南京210009

出　　处：《南京铁道医学院学报》2000年第4期248-249,共2页Journal of Nanjing Railway Medical College

摘　　要：目的 :探讨骨碎补对链霉素耳毒性的解毒作用。方法 :肌肉注射链霉素 (30 0mg·kg-1) 15d制成豚鼠耳聋模型 ,其中部分动物同时用 10 0 %骨碎补液灌胃 (5ml·kg-1)。采用全耳蜗基底膜铺片技术 ,在光镜下计数毛细胞 ,并计算毛细胞损伤百分率。结果 :骨碎补液可使链霉素所致耳蜗一回和二回毛细胞的损伤减轻。结论Objective The purpose of the present study was to analyze the effect of Gusuibu on the ototoxicity by streptomycin.Methods A deafness model was established in 30 guinea pigs by streptomycin (300?mg·kg -1 , i.m.),in which 17 were used as experimental group(32 ears) and 13 as controls(18 ears).The experimental animals were administrated with 100% Gusuibu solution(5?ml·kg -1 )orally.Cochlear pathology was assessed by surface preparation technique.Detail counts of hair cells were recorded under light microscope and analyzed statistically.Result Gusuibu decreased the loss of outer hair cells in the first and second coils.Conclusion Gusuibu may attenuate the ototoxicity by streptomycin.

关 键 词：骨碎补 链霉素 耳毒性 豚鼠 药理 

分 类 号：R978.12[医药卫生—药品] R965.2[医药卫生—药学]