SF/COL/PLCL和SF/COL/PLLA静电纺丝三维纳米纤维支架材料的性能研究  

Materials research of SF/COL/PLCL and SF/COL/PLLA electrospun three-dimensional nanofiber scaffold

作　　者：刘琪[1] 张忠芮 殷丽华[1] 程文晓[1] 秦子顺[1] 余红豆 余占海[1] 

机构地区：[1]兰州大学口腔医学院,兰州730000

出　　处：《功能材料》2014年第3期141-144,共4页Journal of Functional Materials

基　　金：国家自然科学基金青年科学基金资助项目(81102712);甘肃省陇原青年创新人才扶持计划资助项目(B类)

摘　　要：以具有良好生物相容性、生物可降解性的聚乳酸-聚己内酯(PLCL)和聚左旋乳酸(PLLA)为原料,通过静电纺丝法,以70∶30为质量比的SF/COL分别和聚左旋乳酸、聚左旋乳酸-己内酯共混制备不同质量比的纳米纤维支架材料。采用X射线衍射、热重分析等方法对复合材料的理化性能进行表征并对其交联前后的性能进行探讨和比较。结果表明,SF/COL与高分子聚合物复合后其分子结构和热稳定性变化不明显,交联后复合纳米纤维支架β化程度、结晶度和热稳定性较交联前均有所增加,能形成稳定的分子构象,热稳定性有所提高,在组织工程中可为特定细胞提供结构支持,有望成为一种新型的组织工程支架材料。Biocompatible and biodegradable PLCL and PLLA were used as raw material.Through the electrostatic spinning method,with a 70∶30 as mass ratio of SF/COL and PLCL/PLLA blending preparation of nanofiber scaffold materials of different mass ratio.The methods of X-ray diffraction （XRD）,thermogravimetric analysis on the physical and chemical properties of the composites were characterized and their performance were dis-cussed and compared before and after cross-linking.Results showed that SF/COL/polymer composite after its molecular structure and thermal stability change was not obvious.Meanwhile,crosslinked composite nanofibers stent beta degree,crystallinity and thermal stability increased before the crosslinking that could form stable conformation,thermal stability,so it could provide structure for certain cells in the tissue engineering support, which was expected to become a new type of tissue engineering scaffold material.

关 键 词：静电纺丝 聚左旋乳酸 聚左旋乳酸G己内酯 三维纳米支架 

分 类 号：TQ340.64[化学工程—化纤工业]