重复性注射镉金属硫蛋白致小鼠肾脏的急性损害  

ACUTE NEPHROTOXIC IMPACT CAUSED BY MULTIPLE SHORT-INTERVAL INJECTIONS OF CADMIUM-METALLOTHIONEIN IN MICE

作　　者：逄兵[1] 金泰廙[1] 蒋学之[1] 

机构地区：[1]上海医科大学劳动卫生学教研室,上海200032

出　　处：《职业卫生与应急救援》2000年第4期171-173,共3页Occupational Health and Emergency Rescue

摘　　要：目的探讨重复性镉金属硫蛋白（ＣｄＭＴ）注射对实验小鼠肾脏的急性损伤作用。方法末次ＣｄＭＴ染毒６４ｈ后，观察肝、肾组织中镉、钙以及尿液中钙及总蛋白的变化情况。结果随着染镉剂量的增高，肝及肾皮质中钙含量相应增加，并与染镉剂量成明显的剂量－反应关系，而且进入体内的镉主要蓄积在肾脏中；同时尿钙及原蛋白也随着染镉剂量有增加的趋势。结论重复性ＣｄＭＴ染毒主要引起实验性小鼠肾脏的损害，钙稳态失衡是可能的毒作用机制之一。Objective To explore the acute nephrotoxic impact caused by multiple short-interval injections of cadmium-metallothionein (CdMT) in mice. Methods The urinary excretion of calcium and protein and level of calcium and cadmium in kidney cortex were studied at 64h after the last treatment of CdMT. Results The dose-related increases in the level of calcium and cadmium in kidney cortex were found.The excretion of calcium and proteim in urine also increased with the dose of CdMT. Conclusion The results indicated that nephrotoxic impact could be caused by multiple short-interval CdMT injections for mice, and the disturbances of calcium homeostasis may be one of the possible toxicological mechanisms.

关 键 词：镉金属硫蛋白 肾脏毒性 钙稳态 毒理 

分 类 号：R995[医药卫生—毒理学] R992[医药卫生—药学]