神经损伤与单纯制动后骨密度及生物力学改变  

The Changes of Bone Density and Biomechanics in Female Rat following Nerve Injury and Immobilization

作　　者：张宏志[1] 张伯勋[2] 刘郑生[2] 

机构地区：[1]齐齐哈尔解放军第203医院骨科,齐齐哈尔161000 [2]北京解放军总医院骨科

出　　处：《中国矫形外科杂志》2000年第12期1162-1163,共2页Orthopedic Journal of China

摘　　要：目的 :了解神经损伤与制动后骨密度及生物力学改变。方法 :SD大鼠 40只 ,随机分组。术前及术后 12周时分别测量各组大鼠的骨密度。动物处死后行三点弯曲破坏载荷实验。结果 :股骨、胫骨的骨密度改变与对照组及组间相比差异均有显著性 (P <0 .0 1)。各组大鼠股骨、胫骨三点弯曲破坏载荷有下降 ,与对照组相比差异有显著性。股骨、胫骨的骨密度与三点弯曲破坏载荷均呈显著性线性相关。结论 :制动、坐骨神经损伤、脊髓损伤能引起骨量减少 ,骨结构改变 。Objective: To investigate the effects of nerve injury and immobilization on bone density and biomechanics.Methods:40 female SD rats were randomly divided into groups.The BMD of femur、tibia were measured before operation and 12 weeks after operation.Three point bending test was carried out to determine the maximum load of the femur and the tibia after the rats were killed.Results:The BMD changes of the femur and the tibia are statistically significant between the experimental and the control group( P <0.01).The decreases of the maximum load the femur and the tibia are statistically significant between the experimental and the control group( P <0.01).The BMD changes of the femur and the tibia were significantly correlated with the maximum load (r=0.89,0.01< P <0.05;r=0.99, P <0.01).Conclusion:The effect on BMD of the fumur and the tibia by nerve injury and immobilization was significntly different Nerve injury and immobilization induce the decrease of biologic mechanisms.

关 键 词：骨密度 生物力学 肢体制动 神经损伤 

分 类 号：R651.1[医药卫生—外科学]