氟康唑在复发性假丝酵母菌性阴道炎中的临床治疗效果观察  

作　　者：刘蓓[1] 俞泓[2] 徐珩[2] 

机构地区：[1]香港大学深圳医院妇产科,广东518000 [2]深圳市妇幼保健院妇产科

出　　处：《当代医学》2014年第17期64-65,共2页Contemporary Medicine

摘　　要：目的为了探讨临床有效治疗复发性假丝酵母菌性阴道炎的方法，从而为复发性假丝酵母菌性阴道炎的临床相关研究提供科学依据。方法本研究选取了香港大学深圳医院2009年1月～2012年9月期间收治的复发性假丝酵母菌性阴道炎患者172例为研究对象，随机将患者分成2组，分别为对照组和观察组（n=86），对照组给予患者制菌霉素，观察组给予氟康唑治疗。观察比较2组患者实施不同治疗方法半年后的临床治疗效果，以及停药后半年内的复发情况。结果对照组86例患者中治愈78例，治愈率为90．70％；观察组86例患者中治愈85例，治愈率为96．84％，治愈率组间比较观察组患者显著的高于对照组患者，且差异具有统计学意义（χ2=5.7451，p=0.0165）；复发率组间比较，观察组患者的情况明显优于对照组，且差异具有统计学意义（χ2=4.9765，P=0.0257）。结论在临床针对复发性假丝酵母菌性阴道炎患者实施治疗的实践过程中，采用氟康唑实施治疗的临床优势明显，是临床治疗复发性假丝酵母菌性阴道炎的安全可靠选择。Objective To explore the clinical effective method for the treatment of recurrent Candida vaginitis, so as to provide the scientific basis for the clinical research of recurrent Candida vaginitis. Methods This study selected Shenzhen Hospital of Hong Kong University from 2009 January to 2012 September, recurrent Candida vaginitis patients 172 patients as the research object, randomly divided into two groups, which were control group and observation group, 86 cases in each group, the control group patients were given nystatin, the observation group given fluconazole therapy. Clinical observation of the therapeutic effect of two groups were compared after the implementation of half of different treatment methods, and relapse after stopping within half a year. Results In the control group 78 cases were cured in 86 patients, the cure rate was 90.70%; 86 patients in observation group 85 cases were cured, the cure rate was 98.84%, the cure rate between the two groups patients in the observation group were significantly higher than the control group, and the difference was statistically significant （χ2=5.7451,P=-0.0165）; compare the recurrence rate between group, observation group were significantly better than the control group, and the difference was statistically significant χ2=4.9765, P=0.0257）. Conclusion In clinical practice for recurrent Candida vaginitis were treated in the practice process, with obvious clinical advantage of fluconazole therapy, is a safe and reliable choice in the clinical treatment of recurrent Candida vaginiti.

关 键 词：氟康唑 复发性假丝酵母菌性阴道炎 临床效果 

分 类 号：R711.31[医药卫生—妇产科学]