甲磺酸苦柯胺B的化学动力学研究  

Study on the chemical kinetics of kokuamine B mesylate

作　　者：李佳[1] 董凯[2] 韩志东[2] 赵安权 张娇[1] 贺英菊[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]天津红日药业股份有限公司,天津301700

出　　处：《华西药学杂志》2014年第3期292-294,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究甲磺酸苦柯胺B(KB)的化学动力学特征。方法将KB溶液在不同浓度、温度、pH、离子强度等条件下,进行高温加速试验,用HPLC测定其含量变化;通过经典恒温法预测KB溶液的有效期。结果 KB水解反应符合一级动力学方程,反应速率与浓度的一次方成正比;随着温度的升高,KB降解速率显著增大;KB溶液的pH越大,溶液越不稳定,降解速率亦明显增大。离子强度、不同的溶剂及不同的注射液对KB的降解反应亦有一定影响。由Arrhenius公式得到KB溶液降解反应的活化能为62.19 kJ·mol-1;KB水溶液贮存期约为9 d。结论 KB溶液不稳定,降解符合一级反应规律,溶液的温度、pH、离子强度等对其降解均有显著影响。OBJECTIVE TO study the chemical kinetics characteristics of kokuamine B mesylate（KB）. METHODS HPLC method was used to measure the content change of KB solution at the different initial concentration, temperature, pH, ionic strength, etc. under the high temperature accelerated experiment. Also, classical constant temperature method was used to predict the validity of KB solution. RESULTS The hydrolysis reaction of KB conforms to first order kinetics equation. With the temperature rising, the degradation rate of KB increased significantly. And as the pH increases, KB solution was becoming more and more unstable, degradation rate increased significantly. Besides,ionic strength, different solvents and injections all had certain influence on KB＇ s degradation rate. According to the Arrhenius formula, the activation energy of KB solution degradation reaction was estimated to be 62.19 KJ. mol^-1, and the KB solution＇ s storage life was predicted as about 9 days. CONCLUSION The KB solution was unstable, its degradation reaction followed the rules of first order kinetics. The temperature, pH,ionic strength, etc. all had a marked impact on degradation rate of KB solution.

关 键 词：甲磺酸苦柯胺B 化学动力学 高效液相色谱法 

分 类 号：R94[医药卫生—药剂学]