药物雄性生殖毒性及其机制研究进展  

Research progress in pharmaceuticals' male reproductive toxicity and the mechanisms

作　　者：刘絮[1,2] 周莉[2] 孙祖越[2] 

机构地区：[1]复旦大学药学院,上海201203 [2]上海市计划生育科学研究所药理毒理学研究室、中国生育调节药物毒理学检测中心,上海200032

出　　处：《中国新药杂志》2014年第11期1290-1294,共5页Chinese Journal of New Drugs

基　　金：十二五“重大新药创制”科技重大专项(2011ZX09301-005);上海市实验动物创新行动计划项目(11140901300;11140901303)

摘　　要：近年来,随着不孕不育人数的增长,外源性化学物质的生殖毒理学逐渐成为目前毒理学研究的热点。动物实验表明,很多种类的药物都对雄性动物生殖系统有损伤作用,药物对人类造成的生殖毒性正在受到人们的关注。本文将从性行为、生育力、生殖器官、激素、酶、遗传物质等方面介绍药物的雄性生殖毒性的表现,并简述药物引起雄性生殖毒性的机制。In recent years, with the growth of the number of infertility, reproductive toxicology of xenobiot- ics has become a hotspot in toxicology research. The animal experiments showed that many kinds of pharmaceuticals impair reproductive system of the male. More and more attention has been paid to reproductive toxicity of pharmaceuticals on human beings. This paper reviewed the reproductive toxicity of pharmaceuticals on the male from sexu- al behaviour, fertility, reproductive organs, hormones, enzymes, genetics, and so on. Moreover, the mechanisms of male reproductive toxicity caused by pharmaceuticals were covered.

关 键 词：药物 生殖毒性 雄性 

分 类 号：R972.6[医药卫生—药品]