靶控麻醉对直肠癌根治术患者生命体征及免疫功能的影响  

Influence of target controlled infusion on physical sign and immunologic function of patients with radical resection of rectal carcinoma

作　　者：王根生 

机构地区：[1]郑州大学附属肿瘤医院麻醉科,河南郑州450008

出　　处：《实用临床医药杂志》2014年第5期48-50,共3页Journal of Clinical Medicine in Practice

摘　　要：目的分析靶控麻醉对直肠癌根治术患者生命体征及免疫功能的影响。方法选取2011年1月—2012年6月间本院收治并接受直肠癌根治术患者26例,对患者麻醉后生命体征及外周血血清白介素6(IL-6),肿瘤坏死因子(TNF-α),调节性T细胞(Tregs)进行分析。结果患者生命体征各指标均有变化,术中与术前、术后1 h分别比较差异均有统计学意义(P<0.05);血清IL-6、TNF-α浓度术中与术前、术后1 h分别比较差异均有统计学意义(P<0.05);Tregs表达水平术中较术前明显升高(P<0.05),术后1 h与术中比较差异无统计学意义(P>0.05)。结论靶控麻醉对患者生命体征具有一定影响,应注意监测术中各项生命指标,以防止并发症发生,对免疫功能有短期影响,但恢复较快,不会造成长期免疫功能降低。Objective To explore the influence of target controlled infusion （TCI） on physi- cal sign and immunologic function of the patients with radical resection of rectal carcinoma. Methods Post-anesthetic physical sign, levels of IL-6 and TNF-α and change of Tregs in 26 patients with radical resection of rectal carcinoma were analyzed. Results There were significant differences of every index of physical sign and levels of IL-6 and TNF-α in patients between intraoperative period and preoperative and one hour after operation （P 〈 0.05）. There was significant difference of level of Tregs between intraoperative period and preoperative period（P 〈 0.05）. Conclusion TCI shows a certain influence on physical sign of patients, and each index of physical sign should be monitored carefully in order to avoid the incidence of complications. Meanwhile, it shows a short-term influence on the immune function as well, but depending on rapid recovery, this influence won＇t cause a long-term decline of immune function.

关 键 词：靶控麻醉 直肠癌根治术 体征 免疫功能 

分 类 号：R614[医药卫生—麻醉学]