血清铁蛋白在男性2型糖尿病大血管病变发生中的临床价值  

Clinical Value of serum ferritin in occurrence of macroangiopathy in male patients with type 2 diabetes mellitus

作　　者：徐艳[1] 缪小萍[1] 孙峰[2] 

机构地区：[1]江苏省扬州市第一人民医院内分泌科,江苏扬州225002 [2]扬州大学医学院预防医学教研室,江苏扬州225001

出　　处：《实用临床医药杂志》2014年第7期24-26,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨血清铁蛋白(SF)在男性2型糖尿病大血管病变发生中的临床价值。方法回顾性分析2013年7月—2014年1月本院内分泌科住院的70例男性2型糖尿病患者的临床资料,分为有颈动脉病变组和颈动脉正常组,比较2组间各指标差异并进行多因素Logistic回归分析。结果①与颈动脉正常组比较,颈动脉病变组SF水平显著高,2组差异有统计学意义;②通过Spearman相关分析表明,血SF水平与颈动脉病变、体质指数、糖化血红蛋白、甘油三酯、胰岛素抵抗指数等呈显著正相关(P<0.05),与高密度脂蛋白呈显著负相关(P<0.05),与低密度脂蛋白、总胆固醇等无显著相关性。结论 SF升高与男性2型糖尿病动脉粥样硬化的发生、发展呈正相关,SF在男性2型糖尿病大血管病变发生中具有一定的临床价值。Objective To explore the clinical value of serum ferritin （SF） in occurrence of macroangiopathy in male patients with type 2 diabetes mellitus （T2DM）. Methods Clinical materials of 70 male patients with T2DM were analyzed retrospectively. Differences between two groups （T2DM with carotid artery disease and T2DM without carotid artery disease） were compare and analyzed by multivariable Logistic regression. Results Compare with T2DM without carotid artery disease group, the level of SF significantly increased in carotid artery disease group. Spearman analysis showed that the level of SF had a remarkable positive correlation with carotid artery disease, body mass index, hemoglobin A1C, triglyceride and index of insulin resistance respectively （P〈0.05） and a negative correlation with high density lipoprotein（P 〈 0.05）. However, there was no correlation between SF level, low density lipoprotein and total cholesterol. Conclusion Increasing SF level is positively correlated with the development of atherosclerosis in male patients with T2DM, which can be used to reflect the macroangiopathy in male patients with T2DM.

关 键 词：2型糖尿病 男性 动脉粥样硬化 血清铁蛋白 

分 类 号：R587.1[医药卫生—内分泌]