星状神经节阻滞对大鼠乳腺增生模型激素水平的影响  

Effect of stellate ganglion block on hormone level in rats with breast hyperplasia

作　　者：孙志国[1] 蔡海峰[1] 王智云[2] 路延芹[1] 戴浩[1] 

机构地区：[1]河北省唐山市人民医院乳腺二科,河北唐山063000 [2]河北省唐山市人民医院药剂科,河北唐山063000

出　　处：《实用临床医药杂志》2014年第9期58-60,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321658)

摘　　要：目的通过研究星状神经节阻滞(SGB)对于大鼠乳腺增生模型激素水平的调节,进一步探讨其对乳腺增生的影响机制。方法选取40只成年雌性未孕Wistar大鼠随机分成空白对照组、乳腺增生模型组、乳癖消组,乳癖消联合SGB组。对比分析各组大鼠的乳房直径、乳头高度、血清雌二醇(E_2)、黄体酮(P)、催乳素(PRL)水平等指标。结果乳癖消联合SGB组大鼠的E_2、PRL水平下降程度及P水平提高程度与乳癖组相比有显著性差异(P<0.05)。结论对于大鼠乳腺增生模型的干预中,联合应用SGB治疗能够有效调节其激素水平,明显减小乳房直径和乳头高度,达到更加有效的治疗效果。Objective To further explore the function mechanism of stellate ganglion block （SGB）on hormone level in rats with breast hyperplasia.Methods A total of 40 female rats were divided into four groups randomly：blank control group,model group （with breast hyperplasia）, treatment group （with Rubixiao）and combined group （Rupixiao combined with SGB）.The diame-ter of breast,the height of papilla,the levels of estradiol （E2 ）,progesterone （P）and prolactin （PRL）were compared between two groups.Results The difference was significant in the de-creased level of E2 and PRL as well as increased P level between combined group and treatment group （P 〈0.05）.Conclusion In the intervention of rats with breast hyperplasia,combined appli-cation of SGB can effectively regulate the hormone level and reduce the diameter of breast and the height of papilla so as to achieve more superior efficacy.

关 键 词：星状神经节阻滞 乳腺增生 激素 大鼠 模型 

分 类 号：R339.2[医药卫生—人体生理学]