多层螺旋CT在可控性兔急性胰腺炎模型中的诊断价值  

Value of MSCT in diagnosis of controllable rabbit model of acute pancreatitis

作　　者：张紫瑞[1] 崔磊[1] 崔海燕[1] 

机构地区：[1]南通大学第二附属医院影像科,江苏南通226001

出　　处：《实用临床医药杂志》2014年第9期85-87,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨多层螺旋CT在可控性兔急性胰腺炎模型中的诊断价值。方法 16只兔分为正常组3只和实验组13只。实验组采用结扎和胰管注射相结合的方法制作可控性急性胰腺炎模型。测定正常组与实验组造模后4、8 h的血淀粉酶含量,同时采用64层CT进行胰腺平扫及胰腺期、肝脏期的增强扫描。对扫描后的图像进行多平面重建(MPR)、曲面重建(CPR)。结果正常组淀粉酶为(133.12±27.93)U/L,实验组造模后4 h淀粉酶为(263.50±41.73)U/L,造模后8 h为(338.87±75.23)U/L。与正常组比较,实验组造模后4 h的CT平扫和增强胰腺表现无明显异常;造模后8 h的CT表现为胰腺肿大,占84.6%(11/13),平扫时胰腺密度稍低,占38.5%(5/13),胰腺期胰腺密度强化不均匀占53.8%(7/13)。结论对可控性兔急性胰腺炎模型进行多层螺旋CT平扫和胰腺期、肝脏期的增强扫描,对明确急性胰腺炎的发病机制及其早期发展和演变过程具有重要价值。Objective To explore value of MSCT in diagnosis of controllable rabbit model of acute pancreatitis.Methods 16 rabbits were divided into normal group （n =3）and experimental group （n =13）.The experimental group was treated with ligation and injection of pancreatic duct to make the controllable model of acute pancreatitis.The assay of serum amylase and 64-slice CT scan were performed after 4 hours,8 hours of modeling in both groups.The CT scan included plain scan of pancreas,enhancement scanning of pancreatic phase （38 ~43 s）and hepatic phase （52 ~58 s）.Im-ages were retrospectively reconstructed under different reformations of multiplanar reconstruction （MPR）and curved planar reconstruction （CPR）.Results The numerical value of amylase was （133.12 ±27.93）U /L in normal group,and （263.50 ±41.73）U /L after 4 hours of modeling and （338.87 ±75.23）U /L after 8 hours of modeling in experimental group.There was no significant difference of CT scan between experimental group after 4 hours of modeling and the normal group.In the rabbits of 8 hours after modeling,the CT scan showed pancreatic enlargement （11 /13,84.6%）, lower density （5 /13,38.5%）in the plain scan and non-uniform enhancing（7 /13,53.8%）at pan-creatic phase.In experimental group,CT imaging changes of pancreatitis appeared about 4 hours later than amylase changes.Conclusion Implementation of MSCT plain and enhanced scanning for con-trollable rabbit model of acute pancreatitis plays an important value in identifying the pathogenesis and early development process of acute pancreatitis.

关 键 词：胰腺炎 模型 多层螺旋CT 

分 类 号：R657.5[医药卫生—外科学]