雌激素预防绝经后妇女骨质疏松症有效剂量的研究  

The study of the effective does ofextrogen on preventing postmen opamsal Women's osteoporosis

作　　者：杨尧华[1] 于黎明[1] 朱建玲[1] 何秉洁[1] 王岚[1] 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2001年第3期142-144,共3页Ningxia Medical Journal

摘　　要：目的　研究绝经后妇女或子宫及双卵巢切除术后病人骨质疏松症应用雌激素预防的有效剂量。方法　对 12 0例患者给予不同剂量的药物治疗 ,测各剂量组血钙和血磷浓度及骨密度。结果　雌激素 0 .6 2 5mg/d和 1.2 5mg/d的剂量组血钙和血磷显著降低 ,更低剂量组病人骨质丢失明显 (P <0 .0 1)。结论　绝经后每日服用 0 .6 2 5mg雌激素可以预防骨质疏松症 ,更低剂量组则效果差 ,并要定期随访 ,安全性检查子宫及乳腺。Objectives To research the effective does of estngen on preventing the postmen opausal osteoporosis or the isteioirisis women who received gysterectomy and ovariectomy.Methods 120 patients were given different does of estrogen and had been visited for two years in orden to study the of Serum Calciun and phosphorus and the density of bone.Results To the group of estrogen 0.625mg/day and 1.25mg/day,the of serum Calcium and phosphorus significantly decreased.The group of more lower dose of estrogen the losed bone was significant in(P<0.01)。Conclusions Estrogen 0.625mg day can Prevent Postmenopausal osteoporosis,the effect of more lower dosage is not as good as the precious one.at the same time the followmg visit and safety check are needed.

关 键 词：骨质疏松 绝经后 雌激素类 预防 有效剂量 

分 类 号：R984[医药卫生—药品]