鼠血清胰岛素样生长因子水平改变与追赶生长的关系研究  

Studies on Relationship of Serum Insulin like Growth Factors and Catch-up Growth in Rats

作　　者：姚裕家[1] 白波 李炜如[1] 曾懿[1] 杨凡[1] 陈永秀[1] 

机构地区：[1]华西医科大学附属第二医院儿科,成都610041 [2]攀枝花钢铁公司职工医院儿科

出　　处：《中华围产医学杂志》2001年第1期42-44,共3页Chinese Journal of Perinatal Medicine

摘　　要：目的　探讨血清胰岛素样生长因子 (IGFs)水平改变与追赶生长的关系。　方法　钳夹孕鼠双侧子宫动、静脉 ,建立鼠 IU GR模型 ,观察鼠出生时及生后第 3、5天的生长参数、器官重量及血清 IGF- 、 水平。　结果　 (1)出生时 IU GR鼠血清 IGF- 、 的水平及生长参数、器官重量均明显低于对照组 (P均 <0 .0 1)。 (2 )生后第 3天 ,低追赶生长鼠血清 IGF- 、 均明显低于对照组 (P均<0 .0 1) ;高追赶生长鼠血清 IGF- 与对照组差异无显著意义 (P>0 .0 5 ) ;IGF- 水平较对照组明显降低 (P<0 .0 1) ,显著高于出生时的水平 (P<0 .0 1)。(3)生后第 5天 ,IU GR鼠血清 IGF- 、 水平及生长参数、器官重量与对照组差异均无显著意义 (P均 >0 .0 5 )。　结论　 IGF- 、 是追赶生长的重要调节因子 ,其水平的降低可能是 IUGR鼠生后缺乏追赶生长的内在原因之一。Objective To investigate relationship of serum insulin like growth factors(IGFs) and catch up growth. Methods The model of rats intrauterine growth retardation (IUGR) was built by clamping bilateral uterine arteries and veins of pregnant rats. The growth parameters (body weight and length), organs weights (brain, lungs and liver) and serum concentrations of IGF Ⅰ, Ⅱ of all neonatal rats was measured at birth and postnatal day 3 and day 5, respectively. Results (1)At birth, the serum levels of IGF Ⅰ, Ⅱ and the average growth parameters, organs weights in IUGR rats were significantly lower than those in control group( P <0.01).(2)On postnatal day 3, the serum IGF Ⅰ, Ⅱ levels in low catch up growth were all significantly lower than those of control group( P <0.01). There was no difference on IGF Ⅰbetween high catch up and the control groups( P >0.05). The serum of IGF Ⅱ in high catch up group was significantly higher than that at birth( P <0.01), although still lower than that in control group( P <0.01). (3)On postnatal day 5, there was no difference on serum IGF Ⅰ, Ⅱ and growth parameters and organic weight between experimental and control groups( P >0.05). Conclusion Both IGF Ⅰ, Ⅱmay play an important role in the regulation of catch up growth and the decrease of IGF Ⅰ, Ⅱlevels may be the internal factors contributing to the absence of postnatal catch up growth in IUGR rats.

关 键 词：生长调节素类 胎儿生长迟缓 疾病模型 动物模型 

分 类 号：R714.5[医药卫生—妇产科学]