鼻咽癌磁共振成像T分期与血管内皮生长因子蛋白表达的关系  

Relationship between magnetic resonance imaging T-staging and the expression of vascular endothelial growth factor protein in nasopharyngeal carcinoma

作　　者：罗静华[1,2] 杨忠[1,2] 徐坚民[1,2] 单军[1,2] 马捷[1,2] 

机构地区：[1]暨南大学第二临床学院 [2]深圳市人民医院放射科,广东深圳518020

出　　处：《新乡医学院学报》2014年第6期438-439,442,共3页Journal of Xinxiang Medical University

基　　金：深圳市科技计划项目(编号:201002008)

摘　　要：目的探讨鼻咽癌磁共振(MRI)成像肿瘤T分期与血管内皮生长因子(VEGF)蛋白表达的关系。方法收集首次放射治疗前行MRI检查患者48例,用免疫组织化学法检测鼻咽癌组织中VEGF蛋白的表达,分析T分期与VEGF表达的关系。结果 48例患者中T1期13例,T2期11例,T3期11例,T4期13例,VEGF蛋白阳性表达26例(54.2%),其中T1、T2、T3及T4期患者VEGF阳性表达率分别为30.8%(4/13)、45.4%(5/11)、63.6%(7/11)和76.9%(10/13),不同分期之间的VEGF阳性率差异有统计学意义(χ2=32.45,P<0.05),且VEGF蛋白表达阳性率随着鼻咽癌T分期增加而增强的趋势。结论鼻咽癌组织中VEGF有较高的表达,鼻咽癌T分期与VEGF蛋白阳性表达有一定关系,可作为评估肿瘤生物学行为的指标之一。Objective To study the relationship between magnetic resonance imaging（ MRI） T-staging and the expression of vascular endothelial growth factor（ VEGF） protein in the nasopharyngeal carcinoma（ NPC）. Methods A total of 48 patients with NPC whose MRI was performed before treatment were enrolled in this study. The expression of VEGF protein was examined by immunohistochemical technique,and the relationship between MRI T-staging and expression of VEGF protein was analyzed. Results In the 48 patients,there were 13 cases of T1,11 cases of T2,11 cases of T3 and 13 cases of T4. The positive expression of VEGF protein was in 26 cases（ 54. 2%）. The positive-expression rate of VEGF proteins in T1,T2,T3 and T4 were 30. 8%（ 4 /13）,45. 4%（ 5 /11）,63. 6%（ 7 /11） and 76. 9%（ 10 /13）,and the difference among them was statistically significant（ χ2= 32. 45,P 0. 05）. The positive-expression rate of VEGF proteins was increasing with the increasing of T-staging. Conclusion The expression of VEGF protein in NPC is high. The expression of VEGF protein is related to T-staging,and it could be a evaluation index of biological behavior for tumor.

关 键 词：鼻咽肿瘤 磁共振成像 血管内皮生长因子 肿瘤分期 

分 类 号：R965[医药卫生—药理学]