高危型人乳头瘤病毒感染对年轻未婚女性的影响  

Influence of high-risk human papilloma virus infection on young unmarried women

作　　者：潘素招[1] 王新萍[1] 孙依娜[1] 陈珊珊[1] 郑灵芝[1] 

机构地区：[1]台州医院,浙江临海317000

出　　处：《中国卫生检验杂志》2014年第10期1448-1450,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的研究高危型人乳头瘤病毒（HPV）感染对年轻未婚女性宫颈病变的影响，病毒拷贝量与宫颈病变的关系。方法选取25岁以下年轻未婚女性758人进行HPV检测，对HPV检测阳性者，根据HPV拷贝量分3组，HPV在10^4拷贝组；HPV在10。～10。拷贝组；HPV在10^6拷贝以上组。结果共检测高危型HPV758人，阳性171人，阳性率2．3％。HPV检测在10^4拷贝以下26人；HPV在10^4～10^6拷贝116人；HPV在10^6拷贝以上29人。HPV在10^4拷贝以下时宫颈上皮细胞出现病变机会很低；当HPV在10^4～10^6拷贝时，宫颈上皮出现病变但转阴机会大；当HPV在10^6拷贝以上，发展为高度病变的可能性大；年龄在21岁以下未发现宫颈上皮内瘤变（CIN）2—3级病例。结论一个性活跃青少年HPV感染相当普遍，但多数属低度病变。Objective To study the influence of high -risk type human papilloma virus （HPV） infection on cervical lesions of young unmarried females, as well as the correlation between viral load and cervical lesion. Methods A total of 758 unmarried young women under 25 years old were selected for HPV detection, then the HPV positive cases were divided into 3 groups ac- cording to the HPV load（ 10^4 copies group, 10^4 - 10^6 copies group and 〉 10^6 copies group）. Results One hundred and seven- ty- one HPV positive cases were detected from the 758 young unmarried women, accounting for 2.3% （171/758）, including 26 cases with HPV load below 10^4 copies, 116 cases between 10^4 ~ 10^6 copies and 29 cases above 10^6 copies. Cervical epitheli- al ceils lesions were infrequent in unmarried females with HPV load under 10^4 copies. When the HPV load was between 10^4 -10^6 copies, cervical epithelial lesions may appear, but with high proportion of positive -to- negative cases. Severe cervical le- sion was found frequent in females when the HPV load was above 10^6 copies. CIN2 - 3 cases were not found in women under 21 years old. Conclusion HPV infection is general in sexually active adolescents, and most were low- grade lesions.

关 键 词：高危型人乳头瘤病毒 年轻未婚女性 宫颈病变 

分 类 号：R511[医药卫生—内科学]