氯沙坦联合阿托伐他汀对糖尿病肾病内皮功能及血管弹性的影响  

Effect of losartan combined with atorvastatin on endothelial function and arterial elasticity in diabetic nephropathy

作　　者：周秀荣[1] 杨勇[2] 曹茂荣[1] 罗建平[2] 

机构地区：[1]武警黑龙江总队医院心内科,哈尔滨150076 [2]武警总医院心内科,北京100039

出　　处：《武警医学》2014年第5期468-471,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的观察氯沙坦联合阿托伐他汀对糖尿病肾病(diabetic nephropathy,DN)内皮功能及血管弹性的影响。方法 65例糖尿病肾病合并高血压患者,按照随机信封法分为3组:氯沙坦组,50 mg/d;阿托伐他汀组,20 mg/d;联合治疗组,氯沙坦50 mg/d+阿托伐他汀20 mg/d。观察治疗6个月后肱动脉血流介导的血管舒张功能(FMD)和肱-踝动脉脉搏波速度(baPWV)的变化情况。结果治疗6个月后,联合治疗组FMD为(10.61±0.52),与氯沙坦组(7.28±0.59)或阿托伐他汀组(6.87±0.62)比较,差异有统计学意义(P<0.05);联合治疗组baPWV为(8.56±0.44)cm/s,与氯沙坦组(10.8±0.62)cm/s或阿托伐他汀组(11.2±0.41)cm/s比较,差异有统计学意义(P<0.05)。结论氯沙坦和阿托伐他汀联合使用有助于进一步改善DN血管内皮功能及动脉血管的弹性度。Objective To study the effects of losartan combined with atorvastatin on the endothelial function and arterial elasticily elasticity in patients with diabetic nephropathy. Methods A total of 65 patients with diabetic nephropathy were enrolled and randomized to losartan group （only losartan 50 mg/d） , atrovastatin group （only atorvastatin 20 mg/d） and combined group （losartan 50 mg/d ＋ atorvastatin 20 rag/d） by envelopes. The brachial artery flow-mediated dilation （FMD） and brachial-ankle pulse wave velocity （baPWV） were compared among the three groups during six-month follow-up. Results After six-month follow-up, the levels of FMD （10.61 ±0.52） and baPWV （8.56± 0.44 cm/s） in the combined group improved much more significantly than those in losartan group[ FMD： （7.28 ±0.59） ; baPWV： （10.8 ±0.62） cm/s] or atrovastatin group[ FMD： （6.87 ±0.62） ; baPWV： （11.2 ±0.41） cm/s ] （P 〈 0.05 ）. Conclusions Losartan combined with atorvastatin benefits the endothelial function and arterial elasticity in diabetic nephropathy.

关 键 词：氯沙坦 阿托伐他汀 内皮功能 糖尿病肾病 

分 类 号：R331.35[医药卫生—人体生理学]