原发性肾病综合征患儿尿白细胞介素-8的检测及其临床意义  

Clinical value of urine interleukin-8 detection in children with primary nephrotic syndrome

作　　者：郑丽萍 蔡仲仁 蔡丽琴 

机构地区：[1]坪山新区妇幼保健院儿科,广东深圳518122 [2]深圳市龙岗区横岗人民医院检验科,广东深圳518033 [3]深圳市西丽人民医院检验科,广东深圳518052

出　　处：《海南医学》2014年第9期1315-1317,共3页Hainan Medical Journal

摘　　要：目的探讨检测尿白细胞介素-8(IL-8)对原发性肾病综合征(PNS)患儿的临床意义。方法选取40例原发性肾病综合征患儿为观察组,同期于我院行健康体检的40例儿童为对照组。检测并比较两组尿白细胞介素-8水平、尿白细胞介素-6、血浆白蛋白、24 h尿蛋白含量以及T淋巴细胞亚群的变化等。结果 (1)观察组患者CD4+、CD8+、CD4+/CD8+、NK比例均显著低于对照组,差异具有统计学意义(P<0.05)。(2)观察组尿IL-8水平[(5.83±2.15)pg/ml]、IL-6水平[(266.45±54.38)ng/ml]均显著高于对照组的[(2.56±1.24)pg/ml、(107.23±45.15)ng/ml],差异具有统计学意义(P<0.05)。(3)尿IL-8与24 h尿蛋白含量间存在正相关性(r=0.715,P<0.05)。结论原发性肾病综合征患者存在细胞及体液免疫功能紊乱,尿IL-6、IL-8水平检测可作为PNS患儿诊断及疗效判断的参考指标之一。Objective To explore the clinical value of urine interleukin-8 detection in children with primary nephrotic syndrome. Methods 40 patients with nephrotic syndrome were chosen as observation group and 40 healthy children were chosen as the control group. Urine interleukin-8 and interleukin-6, serum albumin, 24h urine protein content and the change of peripheral blood T lymphocyte subsets in each group were detected and compared. Results （1） CD4＋, CD8＋, CD4＋/CD8＋, NK ratio of observation group were significantly lower than that of control group. （2） In observation group, urine IL-8 level [（5.83±2.15） pg/ml） and IL-6 level （266.45±54.38） ng/ml] were sig-nificantly higher than that of control group [（2.56 ± 1.24） pg/ml, （107.23 ± 45.15） ng/ml]. （3） Urine IL-8 and 24h urine protein content had positive correlation （r=0.715, P〈0.05）. Conclusion There were cellular and humoral immune dysfunction in patients with primary nephrotic syndrome. Urine IL-8 and IL-6 levels in children with PNS might be used as reference and one of the indicators to determine the diagnosis and treatment.

关 键 词：白细胞介素-8 肾病综合征 强的松 肾脏 

分 类 号：R692[医药卫生—泌尿科学]