刺五加叶总黄酮固体分散体的制备及其体外评价  

Preparation and Study of Acanthopanax Leaves Total Flavonoids Solid Dispersions In Vitro

作　　者：甘林建 刘静[1] 余泉毅 孙彩霞[1] 尹蓉莉[1] 苏建春[1] 赵俊霞[1] 

机构地区：[1]成都中医药大学药学院,成都611137

出　　处：《世界科学技术-中医药现代化》2014年第4期821-824,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：四川省教育厅青年基金项目(10ZB076):中药浸膏粉末改性技术在固体制剂中的应用研究;负责人:慈志敏

摘　　要：目的:通过制备刺五加叶总黄酮固体分散体,提高其生物利用度。方法:以PEG4000、PEG6000、F68、PVPK30为载体材料制备4种不同的固体分散体,筛选最优载体材料,并考察载体用量对溶出度的影响。以芦丁为对照品,亚硝酸钠-硝酸铝-氢氧化钠为显色体系,用紫外分光光度计在500 nm处测定吸光度,考察各比例固体分散体的体外溶出特性。结果:与原料药相比,以PVPK30为载体材料制得的固体分散体体外释放速率明显提高,并且累积释放度也明显增加。结论:固体分散体能显著提高药物在水中的体外释放度。This study was aimed to prepare solid dispersions of Acanthopanax leaves total flavonoids in order to im-prove its bioavailability. PEG4000, PEG6000, F68, PVPK30 were used as carrier materials in the preparation of four different types of solid dispersion to screen the best type of carrier material and evaluate the amount of carrier mate-rial and its influence on the drug dissolution. Rutin was used as reference substance. NaNO2-Al（NO3）3-NaOH was used as the color system, with a UV spectrophotometer measured absorbance at 500 nm. The dissolution characteris-tics of different proportions of solid dispersions were examined in vitro. The results showed that compared with raw material, the in vitro drug release rate with PVPK30 as carrier material in the obtained solid dispersion of the pro-portion of the raw material was significantly improved, and the cumulative release rate was also increased significant-ly. It was concluded that the solid dispersion prepared by solvent method significantly improved in vitro drug release in water.

关 键 词：刺五加叶总黄酮 载体材料 固体分散体 溶出度 

分 类 号：R284.1[医药卫生—中药学]