青蒿素哌喹片红外光谱鉴别方法的探讨  

Discussion on Analysis of Artemisinin and Piperaquine Tablets by Infrared Spectroscopy

作　　者：闫研[1] 殷果[1] 丁振浩[1] 谭渺 宋茜[2] 王铁杰[1] 

机构地区：[1]深圳市药品检验所/深圳药品质量标准研究重点实验室,深圳518057 [2]沈阳药科大学药学院,沈阳110016

出　　处：《世界科学技术-中医药现代化》2014年第4期921-925,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：经全球基金理事会批准和受中国医药国际交流中心委托;国家药典委员会组织开展的中国全球基金TB结核病项目卫生系统加强(HSS)药品质量标准提高项目(2010-2013年)青蒿素哌喹片国家标准起草(GF2012-40);负责人:王铁杰

摘　　要：目的:对青蒿素哌喹片进行鉴别。方法:采用不同溶剂提取青蒿素哌喹片中的青蒿素和哌喹,分别测定各自红外谱图。结果:除了青蒿素红外光谱图在1 574 cm-1处出现一组哌喹干扰峰外,青蒿素哌喹片经提取后的红外谱图均与《药品红外光谱集》中青蒿素和哌喹标准谱图一致。结论:该方法稳定可靠、专属性强,可用于青蒿素哌喹片的鉴别。Infrared （IR） spectroscopy was employed to identify the Artemisinin and Piperaquine Tablets. Artemisinin and piperaquine was extracted separately by different solvents, and IR spectra were collected. IR absorption spectrum of the extract was concordant with the reference spectrum recorded in the Atlas of Infrared Spectra of Drugs, except for a group of small absorptions at 1 574 cm-1 for the artemisinin extract. It was concluded that IR method is stable and accurate, which can be used to identify the Artemisinin and Piperaquine Tablets.

关 键 词：青蒿素哌喹片 红外光谱 鉴别 

分 类 号：TQ460.72[医药卫生—药物分析学]