复方阿嗪米特肠溶片联合多潘立酮片治疗缺铁性贫血治疗后腹部不适的疗效观察  

Combination of azintamid and domperidone for functional dyspepsia in therapy of iron deficient anemia

作　　者：张青兰[1] 王艳香[1] 

机构地区：[1]郑州市第二人民医院,郑州450006

出　　处：《中南药学》2014年第5期490-492,共3页Central South Pharmacy

摘　　要：目的观察复方阿嗪米特肠溶片联合多潘立酮片治疗缺铁性贫血治疗后腹部不适的效果及安全性。方法经血常规和骨髓化验确诊的缺铁性贫血患者119例,男22例,女97例,随机分为复方阿嗪米特肠溶片+多潘立酮片组(治疗组,84例)和多潘立酮片组(对照组,35例)进行治疗,复方阿嗪米特肠溶片2片/次,3次·d-1,餐后;多潘立酮片1片/次,3次·d-1,餐前0.5 h,疗程均为4周。观察服药前后纳差、餐后饱胀、早饱、上腹痛、上腹烧灼感、嗳气、恶心呕吐、便秘及难以描述的上腹部不适感等症状的积分和药物不良反应情况。结果治疗4周后,治疗组显效率和总有效率优于对照组,差异有统计学意义(P<0.01);治疗组复发率明显低于对照组,差异有统计学意义(P<0.01);2组均未观察到严重的药物相关性不良反应。结论复方阿嗪米特肠溶片联合多潘立酮片治疗缺铁性贫血治疗后腹部不适的疗效满意,复发率低,且安全有效。Objective To study the efficacy and safety of complex azintamide enteric tablet plus domperidone in the treatment of functional dyspepsia. Methods A total of 119 patients with therapy of iron deficient anemia were enrolled in this study. They were randomly divided into a trial group （n = 84） and a control group （n ： 35）. Patients in the trial group took 2 complex azintamide enteric tablets 3 times a day after meals, and domperidone tablets 3 times a day, 0.5 h before meals. Patients in the control group were only given domperidone 1 tablet. The changes in symptom scores of anorexia, postprandial fullness, early satiety, upper abdominal pain, epigastric burning, belching, nausea and vomitting, constipation, the upper abdominal discomfort and other adverse events were observed. Results After treatment for 4 weeks, the efficient in the trial group were significantly lower than that in the control group （P 〈 0.01）. The recurrent rate in the trial group were significantly lower than that of the control group （P 〈 0.01 ）. No servere drug side effect was noted during the treatment course. Conclusion Complex azintamide enteric tablet plus domperi- done tablet show effectiveness and safety in treatment of functional dyspepsia.

关 键 词：阿嗪米特肠溶片 多潘立酮片 缺铁性贫血 腹部不适 

分 类 号：R969.4[医药卫生—药理学]