甘草酸二铵对家兔动脉血管成形术后胶原合成的影响  

Effect of diammonii glycyrrhizinatis on collagen synthesis induced by angioplasty in rabbits

作　　者：匡永东[1] 任江华[1] 王智泉[1] 周毅[1] 

机构地区：[1]武汉大学中南医院心血管内科,湖北武汉430071

出　　处：《中国病理生理杂志》2001年第3期245-247,共3页Chinese Journal of Pathophysiology

摘　　要：目的 :研究甘草酸二铵 (DG)对家兔颈总动脉血管成形术后胶原合成的影响。方法 :用家兔复制成颈总动脉内皮损伤模型 ,4周后检测血清中Ⅰ型前胶原 (PCI)、Ⅲ型前胶原 (PCⅢ )及动脉组织胶原含量 ,并行动脉组织病理形态学检查。结果 :大、小剂量DG治疗组的损伤动脉组织胶原含量 ,血清PCI、PCⅢ含量 ,动脉组织新生内膜厚度和狭窄率均明显低于损伤组。结论 :DG可明显抑制家兔颈总动脉血管成形术后胶原的合成和内膜增生 。AIM: To observe the effect of diammonii glycyrrhizinatis (DG) on collagen synthesis induced by angioplasty in rabbits. METHODS: The right common carotid artery of male rabbits were injured with 3.5F balloon catheter. Four weeks after operation, arterial tissure collagen content, serum procollagen type I(PCI), procollagen type Ⅲ(PCⅢ) concentration, neointimal thickness and the rate of stenosis were measured.RESULTS: Arterial tissue collagen content, serum PCI, PCⅢ concentration, neointimal thickness and the rate of stenosis of low and high dose DG group is lower than those of injured group.CONCLUSION: DG could inhibit collagen synthesis and neointimal proliferation of rabbits carotid artery induced by angioplasty. It suggests that DG might have clinical potential prespective in prevention and therapy of restenosis.

关 键 词：血管成形术 气囊 胶原合成 颈总动脉 PTCA 血管内皮细胞 甘草酸二铵 

分 类 号：R654.2[医药卫生—外科学]