BMSCs对大鼠放射性皮肤损伤的治疗研究  

Study on Stem Cell Therapy of Radiation Skin Injury of Rats

作　　者：陈强[1] 李志满[2] 吴建军[3] 

机构地区：[1]吉林大学公共卫生学院,长春130021 [2]吉林大学实验动物中心,长春130021 [3]吉林大学第二医院,长春130041

出　　处：《实验动物科学》2014年第2期35-37,43,共4页Laboratory Animal Science

基　　金：吉林省科技发展资助项目(No.20102120)

摘　　要：目的探讨通过BMSCs(骨髓间充质干细胞)移植治疗放射性皮肤损伤。方法将放射性皮肤损伤的模型大鼠随机分为干细胞治疗组、阳性药治疗组和对照组。取BMSCs经体外培养后,加于Ⅲ度放射性皮肤损伤的异体大鼠创面上,以平均愈合时间和平均愈合速度为指标,观察各组动物损伤皮肤的修复情况。结果干细胞治疗组皮肤修复速度为(32.37士3.16)mm2/d;平均愈合时间为(20.03士3.95)/d,明显高于其他两组。且组织结构完整、瘫痕小。经统计学处理干细胞治疗组与对照组相比差异有统计学意义(P<0.05)。结论利用同种异体动物干细胞培养物,进行放射性皮肤损伤的治疗有明显的效果,为放射性皮肤损伤的临床治疗提供了一条新途径。Objective To investigate the stem cell therapy of radiation skin injury. Methods The animal were divided into three groups：stem cell group; positive drug group and control group. Bone marrow stromal stem cells were cultured in vitro and then transplanted on the surface of far advanced skin trauma of rats. Results The recovery rate of trauma of experimental group was（32.37 ±3. 16） mm2/d, and the average day of healing up was （20.03 ± 3.95 ） d. All of these were faster than that of control group and the scar of experimental group was smaller than that of control group. There is a significant difference among medium group, experimental group and control group. Conclusion This finding indicates that there is a striking effect on treatment of skin trauma by transplanting stromal stem cells. This study should provide a new method to treatment of radiation skin injuries.

关 键 词：骨髓间充质干细胞 大鼠 放射性皮肤损伤 

分 类 号：Q95-33[生物学—动物学]