血小板相关抗体水平对特发性血小板减少性紫癜预后的价值研究  

Prognostic Value of Expression Level of Platelet-Associated Immunoglobulin in Idiopathic Thrombocytopenic Purpura

作　　者：何学鹏[1] 杨凯[1] 陈鹏[1] 刘兵[1] 张媛[1] 王芳[1] 郭智[1] 刘晓东[1] 楼金星[1] 

机构地区：[1]北京军区总医院血液科,北京100700

出　　处：《国际输血及血液学杂志》2014年第3期216-218,共3页International Journal of Blood Transfusion and Hematology

基　　金：北京市教委产学研合作项目（CXY1002604010）

摘　　要：目的 探讨血小板相关抗体（PAIg）水平在特发性血小板减少性紫癜（ITP）患者中的变化及其对于患者预后的价值.方法 选取北京军区总医院血液内科于2010年11月至2012年10月收治的90例ITP患者作为研究对象,纳入研究组（n=90）;选取同期收治的其他原因导致的血小板减少患者40例纳入对照组（n=40）.通过本院检验科采集研究组和对照组血液标本.采用流式细胞分析技术对患者血小板进行免疫表型检测.回顾性分析研究组及对照组的临床数据：对比两组患者PAIgG、A及M表达水平及血小板计数,并对比研究组接受治疗前、后PAIg表达水平及血小板计数;分析患者PAIg水平及血小板计数变化的相关性.结果 ①研究组治疗前的血小板计数与对照组比较,差异无统计学意义（P＞0.05）,研究组治疗前PAIgG、A及M表达水平均显著高于对照组,差异有统计学意义（P＜0.01）.②研究组经系统治疗后,血小板计数相比于接受治疗前显著增高,差异有统计学意义（P＜0.05）;同时PAIgG、A及M的表达水平均显著减低,差异亦有统计学意义（P＜0.01）.③研究组患者的血小板计数与PAIgG、A及M的表达水平呈显著负相关关系（r=-0,73,-0.68,-0.81;P＜0.05）.结论 PAIgG、A及M表达水平的检测可用于ITP患者的疗效及预后评价.Objective To investigate the change and the prognostic value of platelet-associated immunoglobulin （PAIg） level in idiopathic thrombocytopenic purpura （ITP）.Methods From November 2010 to October 2012,a total of 90 ITP patients in The Military General Hospital of Beijing were collected into this study,as the study group （n=90）,and 40 cases with non-ITP thrombocytopenic in the same period were included in the control group （n =40）.The blood specimens from the study group and the control group were collected at the clinical laboratory.The immunological phenotypes of platelet were analyzed by flow cytometry （FCM）.The clinical data of the two groups were retrospectively analyzed：The expression level of PAIgG,PAIgA,and PAIgM and the platelet count were contrasted between the two groups,and the study group before and after treatment.The relationship between the changes of the PAIg level and the platelet count was analyzed.Results ①There was no significant difference in platelet count between the study group before treatment and the control group （P〉0.05）,but the expression level of PAIgG,PAIgA,and PAIgM was significantly higher in the study group before treatment than the control group（P〈0.01）.②After the treatment,the platelet count in the study group was significantly elevated than before（P〈0.05）,and the expression level of PAIgG,PAIgA,and PAIgM was significantly reduced than before（P〈0.01）.③There was a significant negative correlation between the platelet count and the expression level of PAIgG,PAIgA,PAIgM in the study group（P〈0.05）.Conclusions The expression level of PAIgG,PAIgA,and PAIgM can be used to evaluate the treatment efficacy and the prognosis of ITP.

关 键 词：免疫球蛋白类 血小板 紫癜 血小板减少性 特发性 预后 

分 类 号：R554.6[医药卫生—血液循环系统疾病]