高危型人乳头状瘤病毒阳性不孕患者宫颈感染与组织病变的相关性研究  

Study on correlation between cervical infection and tissue lesions among high risk human papilloma virus positive infertility patients

作　　者：吴崧[1] 赵文龙[1] 郑媛[1] 

机构地区：[1]义乌市中心医院妇产科,浙江义乌322000

出　　处：《中华医院感染学杂志》2014年第12期2877-2879,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨高危型人乳头状瘤病毒(HPV)阳性不孕患者宫颈支原体属和衣原体属感染与宫颈组织病变之间的相关性,为其诊疗提供理论依据。方法选择2012年1月-2013年4月妇科门诊就诊的不孕患者372例,其中高危型HPV感染阳性者188例,收集其宫颈脱落细胞,检测患者高危型HPV及支原体属和衣原体属感染,记录分析高危型HPV感染及宫颈支原体属和衣原体属感染时宫颈组织病变发生的差异。结果 372例不孕患者中高危型HPV感染阳性者188例,感染率为50.53%,高危型HPV感染阳性者中支原体属感染106例、衣原体属感染16例,感染率分别为56.38%、8.51%,而高危型HPV感染阴性者中支原体属感染64例、衣原体属感染10例,感染率分别为34.78%、5.43%,支原体属感染中高危型HPV感染阳性者高于阴性者,差异有统计学意义(P<0.05);188例高危型HPV感染阳性患者发生CIN共48例,发生率25.53%;高危型HPV感染并发支原体属感染患者发生CINⅠ共20例发生率为20.41%、发生CINⅡ+CINⅢ共10例发生率为10.20%。结论高危型HPV感染阳性不孕患者并发宫颈支原体属和衣原体属感染,是导致宫颈组织病理改变的原因。OBJECTIVE To investigate the correlation between cervical Mycoplasma and Chlamida infection and cervical tissue lesions among HR HPV positive infertility patients so as to provide a theoretical basis for its diagnosis and treatment .METHODS A total of 372 cases of fertility patients treated in gynecology clinic from Jan 2012 to Apr 2013 were collected ,with 188 cases of patients presenting HR-HPV positive;the cervical exfoliated cells were collected to detect the HR-HPV infection and the Mycoplasma and Chlamydia infection ,and to record the differences between the cervical tissue lesions occurred when the patients suffering HR-HPV , cervical Mycoplasma infection ,and cervical Mhlamydia infection .RESULTS Totally ,188 of the 372 cases of fertility patients suffered HR- HPV infection positive ,with the infection rate of 50 .53% ;106 cases of the HR-HPV infection positive patients suffered Mycoplasma infection and 16 cases suffered Chlamydia infection ,accounting for 56 .38% and 8 .51% respectively ;while ,64 cases of the HR-HPV infection negative patients suffered Myco-plasma infection and 10 cases suffered Chlamydia infection ,accounting for 34 .78% and 5 .43% respectively ;of the Mycoplasma infection patients , HR-HPV infection positive patients were more than HR-HPV infection negative patients ,and there was significant difference（P〈 0 .05）;among the 188 cases of HR-HPV infection positive patients ,48 patients suffered CIN ,with the infection rate of 25 .53% ;20 patients complicated with HR-HPV infection and Mycoplasma infection suffered CIN Ⅰ ,with the infection rate of 20 .41% ;10 cases of patients suffered CIN Ⅱ ＋CIN Ⅲ ,with the infection rate of 10 .20% .CONCLUSIONS Complication of Mycoplas-ma and Chlamydia infection is the reason inducing cervical tissue lesion to high-risk HPV infection positive infertility patients .

关 键 词：高危型人乳头状瘤病毒 支原体属 衣原体属 宫颈组织 病理 不孕患者 

分 类 号：R373[医药卫生—病原生物学]