足月胎膜早破产妇与新生儿感染的临床研究  

Premature rupture of membranes of maternals with full-term pregnancy and neonatal infections

作　　者：朱静维 周华[2] 李周 

机构地区：[1]宁波市鄞州区咸祥中心卫生院妇产科,浙江宁波315141 [2]浙江省人民医院妇产科,浙江杭州310014

出　　处：《中华医院感染学杂志》2014年第12期3067-3069,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(30800347)

摘　　要：目的通过足月妊娠产妇胎膜早破对产妇及新生儿感染发生的影响分析,为临床预防和减少产妇感染提供可靠的参考依据。方法选取2010年6月-2013年6月妊娠>37周且无妊娠并发症非外力或机械性刺激导致的胎膜早破孕妇126例为观察组,在同期、同龄非胎膜早破的健康产妇121名作为对照组1,同期、同龄孕前检查的健康女性120名为对照组2,对3组受试者阴道分泌物进行微生物检查,同时检测分泌物中免疫调节因子白介素2(IL-2)、白介素6(IL-6)及肿瘤坏死因子α(TNF-α)的水平,并统计两组产妇围产期感染及新生儿感染。结果观察组产妇感染9例感染率7.14%,新生儿感染7例感染率5.79%,对照组1产妇感染1例感染率2.83%,无新生儿感染病例;观察组产妇及新生儿感染率均低于对照组1,差异有统计学意义(P<0.05);观察组乳杆菌属检出率为46.83%,低于对照组1的69.42%及对照组2的82.50%,观察组大肠埃希菌检出率53.97%,高于对照组1的41.32%及对照组2的43.33%;观察组阴道分泌物中IL-6、TNF-α高于对照组1、2,差异有统计学意义(P<0.05);IL-2低于对照组1、2,其中与对照组2比较差异有统计学意义(P<0.05)。结论足月胎膜早破也会导致产妇及新生儿感染升高,而阴道菌群失调可能是导致感染增加的原因,预产期产妇进行相关检查及治疗,预防菌群失调导致的胎膜早破发生,降低足月新生儿及产妇的感染可能性。OBJECTIVE To analyze the influence of premature rupture of membrane of the maternals with full-term pregnancy on incidence of infections in the maternals and neonates so as to provide reliable basis for prevention of infections .METHODS From Jun 2010 to Jun 2013 ,totally 126 maternals with the pregnancy more than 37 weeks who suffered from the premature rupture of membrane that was not induced by the pregnancy complication or mechanical irritation were chosen as the observation group ,meanwhile ,121 healthy maternals without premature rupture of membrane were set as the control group 1 ,120 healthy women who underwent pregnancy examination were selected as the control group 2 , then the vaginal secretions were sampled from the three groups of participants for microorganism test ;the levels of interleukin-2 （IL-2） ,interleukin-6 ,and tumor necrosis factor-α（TNF-α） in the secretions were tested ;the incidence of perinatal infections in the maternal and the incidence of infections in the neonates were statistically analyzed .RESULTS There were 9 （7 .14% ） maternals with infections and 7 （5 .79% ） neonates with infections in the observation group ;there were 1 （2 .83% ） maternal with infections and no neonate with infections in the control group 1 ;the incidence of infections in the maternals or neonates was lower in the observation group than in the control group 1 , the difference was significant （ P〈 0 .05 ） . The isolation rate of L actobacillus was 46 .83% in the observation group ,lower than 69 .42% in the control group 1 and 82 .50% in the control group 2 ;the isolation rate of Escherichia coli was 53 .97% in the observation group , higher than 41 .32% in the control group 1 and 43 .33% in the control group 2 .The levels of IL-6 and TNF-αin the vaginal secretions were higher in the observation group than in the control group 1 and the control group 2 ,the difference was significant ;the level of IL-2 of the observation group was lower than that of the control group 1 and the contro

关 键 词：胎膜早破 足月 产妇 新生儿 感染 研究 

分 类 号：R714.433[医药卫生—妇产科学]