支原体肺炎患儿医院感染的危险因素分析  

Risk factors for Mycoplasma pneumoniae infections in children

作　　者：黄洋[1] 杨磊[1] 张琳[2] 

机构地区：[1]湖北省妇幼保健院儿内科,湖北武汉430070 [2]郧阳医学院附属人民医院内科,湖北郧阳442000

出　　处：《中华医院感染学杂志》2014年第12期3070-3071,3074,共3页Chinese Journal of Nosocomiology

基　　金：湖北省卫生厅科研基金资助项目(JX2B92)

摘　　要：目的探讨小儿难治性支原体肺炎(MPP)医院感染发生的危险因素,以降低难治性MPP患儿的医院感染率,并为防止难治性MPP患儿发生医院感染提供参考依据。方法将2011年1月-2012年12月120例难治性MPP患儿中发生医院感染的48例作为感染组,其余72例为非感染组,对导致难治性MPP发生医院感染的高危因素进行单因素分析,然后采用多因素logistic回归分析方法,找出独立危险因素,应用SPSSl7.0统计软件进行统计分析。结果 120例难治性MPP患儿中发生医院感染48例,感染率为40.0%;单因素分析显示,年龄<2岁、住院时间≥2周、季节、侵入性操作、补体C3及C-反应蛋白水平升高与医院感染的发生有关(P<0.05);多因素logistic回归分析显示,补体C3水平低下、年龄<2岁、侵入性操作、C-反应蛋白>60mg/L是难治性MPP发生医院感染的独立危险因素。结论补体C3水平低下、年龄<2岁、流行接触史、C-反应蛋白>60mg/L是儿童难治性MPP的独立危险因素,对具有这些危险因素的患儿应予以高度重视,以减少难治性MPP医院感染的发生及其对患儿的危害。OBJECTIVE To explore the risk factors for refractory Mycoplasma pneumoniae infections in children , reduce the incidence of nosocomial infections in the children with refractory M ycoplasma pneumoniae pneumonia （MPP） and provide guidance for control of nosocomial infections in the children with refractory MPP .METHODS A total of 120 children with refractory MPP who were treated in the hospital from Jan 2011 to Dec 2012 were enrolled in the study , then 48 children complicated with nosocomial infections were assigned as the infection group ,the rest of 72 children were set as the control group ,the univariate analysis was performed for the high risk factors for the nosocomial infections in the children with refractory MPP ,the independent risk factors were found out by means of multivariate logistic regression analysis ,the statistical analysis was performed with the use of SPSS17 .0 software .RESULTS Of the 120 children with refractory MPP ,the nosocomial infections occurred in 48 cases with the infection rate of 40 .0% .The univariate analysis indicated that less than 2 years of age ,length of hospital stay no less than 2 weeks ,seasons ,invasive operation ,complement C3 ,and elevated level of C-reactive protein were related to the incidence of nosocomial infections .The multivariate logistic regression analysis showed that the low level of complement C3 ,less than 2 years of age ,invasive operation ,and level of C-reactive protein more than 60 mg/L were the independent risk factors for nosocomial infections .CONCLUSIONS The low level of complement C3 ,less than 2 years of age ,history of contacting with epidemic ,and level of C-reactive protein more than 60 mg/L are the independent risk factors for the children with refractory MPP .It is necessary to pay high attention to the risk factors so as to reduce the incidence of nosocomial infections in the children with refractory M PP and protect the children against the harm .

关 键 词：肺炎支原体 肺炎 危险因素 儿童 

分 类 号：R725.6[医药卫生—儿科]