儿童皮肤软组织感染金黄色葡萄球菌药敏分析  

Analysis of drug sensitivity of Staphylococcus aureus in children with skin and soft tissue infections

作　　者：李瑞英[1] 张志芳[1] 刘晓娟[1] 

机构地区：[1]郑州人民医院儿科,河南郑州450003

出　　处：《中华医院感染学杂志》2014年第12期3080-3081,3084,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(10971168)

摘　　要：目的分析儿童皮肤软组织感染(SSTIs)中金黄色葡萄球菌(SAU)的临床特征、耐药性,并探讨相关预防与治疗对策。方法选取医院2008年9月-2010年9月收治的461例SAU导致的SSTIs患儿,对其发病年龄、性别、科室分布等临床特征进行对比,并分析SAU耐药性,探讨预防控制对策,数据采用SPSS13.0进行分析,药敏数据使用WHONET5.3软件进行统计。结果 461例SAU致SSTIs感染患儿中儿科病区332例,占72.02%,其构成比显著高于新生儿科及儿童内科,差异有统计学意义(P<0.05);患儿感染部位多集中于手指甲沟、脐部、脚趾甲沟及颈部,分别占13.45%、17.14%、13.02%及12.36%;SAU对青霉素、红霉素和克林霉素耐药率较高,分别为83.51%、72.89%及65.51%,对万古霉素、头孢地尼、苯唑西林敏感率较高,分别为100.00%、90.46%及87.42%。结论对于SSTIs患儿,应按照SAU的药敏分析结果选择敏感率较高的抗菌药物治疗,并注重日常护理,以及时缓解患儿感染症状,保证其健康生长。OBJECTIVE To analyze the clinical features and drug resistance of the Staphylococcus aureus （SAU） in the children with skin and soft tissue infections （SSTIs） ,and to explore the related prevention and treatment strategies .METHODS A total of 461 children with SSTIs caused by SAU ,who were treated in the hospital from Sep 2008 to Sep 2010 ,were selected to compare their clinical characteristics such as age of onset ,gender and distribution of departments ,the SAU drug resistance and the preventive and control measures were exploved . SPSS13 .0 software was adopted for statistical analysis ,while WHONET5 .3 software package was used to analyze data from the drug susceptibility test .RESULTS Among the 461 children with SSTIs caused by SAU ,the pediatric ward accounted for 72 .02% ,the constituent ratio of which was significantly higher than that in the neonatology department and children′s medical department ,the difference was significant （P〈0 .05）;the infection positions took mostly at the fingernail grooves , umbilical region , toenail grooves and cervical region , each of which accounted for 13 .45% ,17 .14% ,13 .02% and 12 .36% , respectively .SAU had a high drug resistance to penicillin ,erythromycin and clindamycin ,with a resistant rate of 83 .51% ,72 .89% and 65 .51% ,respectively ;SAU was highly sensitive to vancomycin ,cefdinir and oxacillin ,with a sensitive rate of 100 .00% ,90 .46% and 87 .42% ,respectively .CONCLUSION For children with SSTIs ,it＇s needed to choose antimicrobials with a high sensitivity rate for treatment in accordance with the drug sensitivity analysis results for SAU and pay attention to daily care ,so as to relieve the symptoms of infections in children in a timely manner and ensure their healthy growth .

关 键 词：儿童 皮肤软组织 感染 金黄色葡萄球菌 药敏分析 

分 类 号：R379.5[医药卫生—病原生物学]