异烟肼巴布剂处方的优选  

Optimization of the formula of isoniazid cataplasm

作　　者：容露萍[1] 廖华卫[2] 陶涛[1] 

机构地区：[1]广州市胸科医院药剂科,广州510095 [2]广东药学院中药学院中药研究室,广州510006

出　　处：《中国临床药学杂志》2014年第3期170-173,共4页Chinese Journal of Clinical Pharmacy

基　　金：广州市医药卫生科技项目(编号20131A011076)

摘　　要：目的采用正交试验筛选异烟肼巴布剂的处方。方法以膜残留和涂展性为评价指标进行正交试验,确定最佳处方。结果异烟肼巴布剂处方组成是主药异烟肼∶黏着剂(质量比是1∶3的卡波姆∶NP700)∶保湿剂(甘油)∶交联剂(甘羟铝)=3∶6∶30∶0.1。结论异烟肼巴布剂处方设计较为合理,可进一步开发。AIM To optimization of the formula of isoniazid cataplasm by orthogonal experiment. METHODS The formula of isoniazid eataplasm was optimized by orthogonal experiment based on two factors ： film residue and spreadability. RESULTS The formula of isoniazid cataplasm was as following：isoniazid was 3 g, 1：3 mass ratio of earbomer： NP700 as adhesive was 6 g, glyeefin as a humeetant was 30 g, and dihydroxyaluminium aminoaeetate as erosslinkers was 0. 1 g. CONCLUSION The formula of isoniazid cataplasm is reasonable and it is worth doing further research.

关 键 词：异烟肼巴布剂 正交试验法 黏着剂 保湿剂 交联剂 处方筛选 

分 类 号：R944[医药卫生—药剂学]