凝集素样氧化低密度脂蛋白受体-1与男性阻塞性睡眠呼吸暂停低通气综合征的相关性  

Relationship of Soluble Lectin-Like Oxidized LDL Receptor 1 with Severe Obstructive Sleep Apnea-Hypopnea Syndrome in Men

作　　者：石宏伟[1] 蒲鹏[1] 邓伟[1] 周恒[1] 江洪[1] 罗志宏[2] 唐其柱[1] 

机构地区：[1]武汉大学人民医院心血管内科,湖北武汉430060 [2]武汉大学人民医院耳鼻喉头颈外科,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2014年第3期403-406,共4页Medical Journal of Wuhan University

基　　金：国家创新性大学生科研项目(编号:101048637)

摘　　要：目的:研究凝集素样氧化低密度脂蛋白受体-1(sLOX-1)在男性阻塞性睡眠呼吸暂停低通气综合征患者(OSAHS)中的水平。方法:选取2011年9月-2012年6月于武汉大学人民医院鼾症中心住院的102例男性患者行多导睡眠监测,进一步分为轻度组(n=24),中度组(n=14)和重度组(n=64)。ELISA法监测患者血清sLOX-1水平,并在1月后随访。结果:对正常对照组、轻度和中度OSAHS患者相比,重度OSAHS患者血清sLOX1水平升高,血清sLOX1水平与夜间平均血压、总甘油三酯(TG)、呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO2)水平呈正相关。1个月后随访,重度OSAHS患者血清sLOX1水平明显降低(P<0.001)。结论:血清sLOX-1与重度OSAHS密切相关,男性阻塞性睡眠呼吸暂停低通气综合征患者sLOX-1水平升高。Objective： To study the changes of soluble lectin-like oxidized LDL receptor 1 （sLOX-1） in male patients with obstructive sleep apnea-hypopnea syndrome （OSAHS）. Methods： A total of 102 male patients with OSAHS and 16 controls were enrolled in the study, from September 2011 to June 2012. Patients with OSAHS were further divided into mild （n=24）, moderate （n=14） and severe OSAHS groups （n=64）. Serum sLOX-1 concentration was measured by ELISA kit before treatment and one month after treatment. Results： The sLOXl levels in the severe OSAHS group were significantly higher than in mild OSAHS, moderate OSAHS and control groups. Serum levels of sLOX-1 were correlated positively with mean blood pressure （night）, serum triglyc- eride （TG）, AHI, and LSaO2. Circulating sLOX-1 was independently associated with AHI by a multiple regression analysis, sLOX-1 levels were significantly reduced （P〈0. 001） after a month of treatment. Conclusion. High levels of sLOX-1 were closely linked with the presence of severe OSAHS. Elevated sLOX-1 were found in male patients with OSAHS.

关 键 词：男性 阻塞性睡眠呼吸暂停低通气综合征 凝集素样氧化低密度脂蛋白受体-1 

分 类 号：R541.6[医药卫生—心血管疾病]