一种潜在的新肿瘤分子标志物RASSF4的研究进展  

Progress in A New Potential Tumor Molecular Marker of RASSF4

作　　者：张凤凤[1] 刘永娟[1] 朱果果[1] 程青青[1] 王志浩[1] 刘万红[1] 何小华[1] 

机构地区：[1]武汉大学基础医学院过敏及免疫相关疾病湖北省重点实验室,湖北武汉430071

出　　处：《武汉大学学报（医学版）》2014年第3期484-488,共5页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助项目(编号:81171577;81371790);中央高校基本科研业务费专项资金资助项目(编号:20113010202001;2012301020207)

摘　　要：RAS相关结构域家族(RASSFs)由10个成员组成,这些家族成员已被确认为抑癌基因,可以通过多种途径调控细胞增殖、促进细胞凋亡和衰老,维持微管的稳定性、调节细胞的黏附和运动性。研究发现RASSF4在正常组织中广泛表达,而在人类肿瘤细胞中由于启动子甲基化表达下调,RASSF4还可诱导细胞凋亡,其关于信号转导途径的研究也有了一定发展。本文就其研究进展进行综述。The RAS-association domain family （RASSFs） contains l0 members, which have all been confirmed to be the tumor suppressor genes, are related to the inhibition of cell growth, induc- tion of cell apoptosis, aging and the stability of microtubules, and cell adhesion and motility. Re- cently, RASSF4 is found to be expressed broadly in normal tissue, while it is frequently down- regulated by the methylation of the promoter region in human tumor cells. RASSF4 can also in- duce cell apoptosis. The study of its signal transduction pathways also have reached to a certain extent. Here we review the current research progress on RASSF4.

关 键 词：RAS相关结构域家族 RASSF4 甲基化 细胞凋亡 

分 类 号：R392.9[医药卫生—免疫学]