补肾益精方提高绝经后骨质疏松症大鼠模型松质骨骨质量的作用及其机制的研究  

STUDY ON THE MECHANISM OF BSYJF, A TRADITIONAL CHINESE PRESCRIPTION, RAISING BONE QUALITY OF CANCELLOUS BONE IN OSTEOPOROTIC RAT MODEL INDUCED BY OVARIECTOMY

作　　者：张戈[1] 石印玉[1] 赵咏芳[1] 沈培芝[1] 徐宇[1] 朱太咏 

机构地区：[1]上海中医药大学附属曙光医院骨伤科,200021 [2]河南省洛阳正骨研究所生物医学工程研究室,471002

出　　处：《医用生物力学》2001年第1期18-22,共5页Journal of Medical Biomechanics

基　　金：国家95攻关科研基金资助!(969060905)

摘　　要：评价补肾益精方提高切卵术诱导的绝经后骨质疏松症大鼠模型松质骨骨质量的有效性并且探讨本方的作用机制。方法：４０只１２月龄Ｗｉｓｔａｒ雌性大鼠随机分为正常组、模型组、补肾益精方组与倍美力组。处死以后，分别测定大鼠第二腰椎骨生物力学性能等参数。结果：各组腰椎宏观几何结构参数未见明显差异。与正常组比较，模型组的骨矿盐密度显著减少，骨胶原密度减少不显著；各用药组与模型组比较，补肾益精方组的骨矿盐密度与骨胶原密度分别上升３％和８％，倍美力组分别上升９％和１２％。模型组的力学参数显著低于正常组；补肾益精方组的弹性阶段的力学参数比模型组显著升高，但是倍美力组升高不显著；各用药组塑性阶段的力学参数与模型组比较均明显升高。结论：补肾益精方不仅能够提高模型松质骨的骨质量，而且改善模型松质骨弹性阶段的力学性能的作用相对优于倍美力。Objective:To evaluate the efficacy of BSYJF on raising the quality of cacellous bone of vertebrate in osteoposrotic rat model induced by ovariectomy and to inquiry into the mechanism on improving biomechanical propelties of cancellous bone. Method:Forty 12-month-old female Wistar rats were divided randomizedly into four groups:Sham control group,Ovx contral group,BSYJF group(Ovx+BSYJF) and BML group(Ovx+BML). After sacrifice, biomechanical parameters and other parameters of No.2 lulmbar vertebrate were determined. Results:The macroscopic geometry structure(height and volume) in Ovx control group, BSYJF group and BML group were not altered siguificantgroup were reduced by 11% (p<0.05) and 6% (p >0.05 ),respectively vs Sham control group. In comparison with those Of Ovx control group,the BMD and the BCD in BSYJF group were increased by 3% (p<0.05) and 8% (p> 0.05),and the BMD and the BCD in BML group were increased by 9% (p<0.05) and 12% (p>0.05).The mechanical parameters in Ovx control group were all decreased significantly (p<0.05),respectively vs Sham control group.Especially,in elastic phase,the mechanical parameter in BSYJF group were increased significantly (p <0.05 ),vs Ovx control group;but those in BML group were not increased significantly (p >0. 05 ),vs Ovx control group. In plastic phase,the mechanical parameters were increasedsignificantly,respectively vs Ovx control group.Conclusion:BSYJF can not only raise the quality of cancellous bone of vertebrate in the rat model induced by ovariectomy,but also have superiority to BML in improving the cancellous bone mechanical property in elastic phase.

关 键 词：补肾益精方 骨质量 生物力学 绝经后 骨质疏松 大鼠 

分 类 号：R271.917.5[医药卫生—中西医结合] R274.91[医药卫生—中医妇科学]