肺部手术围手术期氨溴索剂量的选择研究  

Perioperative dosing schemes for ambroxol in patients scheduled for lung surgery

作　　者：吴国栋[1] 彭学锋[1] 罗伟彬[1] 

机构地区：[1]深圳市第二人民医院,广东深圳518000

出　　处：《广州医学院学报》2013年第6期48-50,共3页Academic Journal of Guangzhou Medical College

基　　金：深圳市科技计划项目(201203055)

摘　　要：目的:探讨肺部手术围手术期氨溴索的合适剂量。方法:选择在深圳市第二人民医院实施肺部手术的295例患者作为研究对象,分为对照组和A、B、C、D治疗组,每组各59例。A、B、C、D组术后分别使用30、60、90、120 mg盐酸氨溴索,对照组使用生理盐水100 mL。比较各组术后排痰情况、并发症发生率及抗生素使用时间。结果:治疗组治愈率、好转率高于对照组(P<0.05);C、D组治愈率、好转率均高于A、B组(P<0.05)。对照组并发症发生率高于治疗;A、B组并发症发生率高于C、D组(P<0.05)。对照组抗生素使用时间长于治疗组(P<0.05),A、B、C组抗生素使用时间长于D组(P<0.05)。结论:氨溴索可有效防止肺部手术围手术期的呼吸系统并发症,其临床剂量使用应适当偏用高剂量,具体最适剂量仍待进一步探索。Objective：To investigate the appropriate perioperative dosing scheme for ambroxol in patients scheduled for lung surgery. Methods： We randomly allocated 295 patients who were scheduled for lung surgeries in Shenzhen Second People＇ s Hospital to be treated with 100 mL natural saline intravenous injection （ control group, n = 59 ） , 30 mg ambroxol thrice daily （ group A, n = 59 ） , 60 mg ambroxol thrice daily （ group B, n = 59） , 90 mg ambroxol thrice daily （group C, n = 59 ） and 120 mg ambroxol thrice daily （group D, n = 59 ） , respectively. We next compared the volume of sputum expectorated, the incidence of respiratory complications and the use of antibiotics. Results： Compared with control group, all treatment groups yielded a significantly higher rates of recovery and remission yet a lower incidence rate of complications （ all P 〈 0.05 ）. This held true for the comparisons between groups C and D, and between groups A and B （ both P 〈 0. 05 ）. The control group was associated with a prolonged period of antibiotic use （all P 〈 0.05）. Compared with groups A, B and C, a longer period of antibiotic use was noted in group D （ all P 〈 0.05 ）. Conclusions： Ambroxol effectively prevents from the incidence of perioperative respiratory complications. Despite that relatively high doses of ambroxol are recommended for clinical application, the optical doses merits further studies.

关 键 词：氨溴索 围手术期 并发症 肺部手术 

分 类 号：R562.1[医药卫生—呼吸系统]