轻度烧伤后红细胞流变学特性的变化  

Changes in Erythrocyte Rheologic Properties after Mild Burn Injury

作　　者：宋立川[1] 崔和勤[1] 李占军[1] 张硕森[1] 刘红[1] 张树峰[1] 

机构地区：[1]华北煤炭医学院基础部,唐山063000

出　　处：《生物医学工程学杂志》2001年第1期72-75,共4页Journal of Biomedical Engineering

摘　　要：我们用轻度烧伤动物模型研究了烧伤后红细胞 (RBC)变形性及渗透脆性的变化。结果发现 ,轻度烧伤后红细胞变形性随时间有一先抑后扬的变化趋势。烧伤后立即取血 (0 h)所测结果与烧伤前比较 ,RBC最大变形指数 (DI) m ax、积分变形指数 IDI及红细胞渗透脆性都未见显著性差异 ;烧伤后 1、2 h时 (DI) m ax、IDI显著降低 (P<0 .0 1或 P<0 .0 5 ) ;4、7h时 (DI) max、IDI虽略低于烧伤前水平 ,但未见显著性差异 (P>0 .0 5 )。烧伤后不同时间点(0、1、2、4、7h)所取血样的 RBC渗透脆性与烧伤前比较 ,除在烧伤后 4h时显著增加外 ,在其余各时间点均未见显著变化。说明在用该动物模型所得结果中 ,(DI) max、IDI的受损及 RBC渗透脆性的增加 ,可能都只与体液因素的作用有关。但 RBC变形性的受损与其渗透脆性的变化不是同步的 。The changes in erythrocyte deformability and osmotic fragility were studied with an animal model of mild burn injury. The results showed that after the burn injury there was a gradual decrease with time at first and then a recovery in erythrocyte deformability. Maximum deformation index [(DI)max], integration deformation index (IDI) and osmotic fragility of RBCs drawn just after burn were almost identical to those before burn injury. (DI)max and IDI significantly decreased at 1, 2 h but not at 4, 7 h when compared with those before burn injury, however, the RBCs were less deformable at 4, 7 h. Erythrocyte osmotic fragility significantly increased only at 4 h after burn injury when compared at the time points of 0, 1, 2, 4, 7 h after burn with that before burn injury. The results indicated that the lesion in (DI)max and IDI, and the increase in osmotic fragility might be only related to the body fluid factors in this animal model. The decrease in erythrocyte deformability and the increase in erythrocyte osmotic fragility did not synchronize, suggesting that the changes might come about not by the same mechanism.

关 键 词：烧伤 红细胞 红细胞变形性 渗透脆性 

分 类 号：R644[医药卫生—外科学] R318.01[医药卫生—临床医学]