姜黄素对急性肺动脉栓塞大鼠肺损伤及CFTR表达的影响  

Role of curcurmin in acute lung injury by acute pulmonary embolism and expression of CFTR

作　　者：王征[1] 玉寒冰[1] 罗全[1] 

机构地区：[1]辽宁省肿瘤医院胸外科,辽宁沈阳110042

出　　处：《现代肿瘤医学》2014年第6期1242-1244,共3页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:No:30901477/HO109)

摘　　要：目的:观察姜黄素对急性肺栓塞大鼠肺损伤的保护作用及对CFTR表达的影响。方法:大鼠分为假手术组,模型组,姜黄素(150mg/kg)+APE组。制备左肺动脉结扎模拟急性肺动脉栓塞模型。进行血气分析,检测AFC及肺湿干比,real-time PCR方法检测肺组织的CFTR的表达。结果:与模型组比较,姜黄素升高PaO2水平,减轻AFC下降趋势,及减少肺湿干比的增加。姜黄素能提高肺组织的CFTR的表达。结论:姜黄素对急性肺动脉栓塞大鼠的急性肺损伤有保护作用,并上调CFTR的表达。Objective：To observe whether the curcumin could protect the acute lung injury by acute lung embolism and affect the expression of CFTR. Methods：SPF rats were divided into 3 groups：sham group,acute pulmonary em-bolism（APE）group and curcumin group（150mg/kg）. The model of acute pulmonary embolism was ligatured the left artery. Blood gas analysis,AFC and wet-to-dry ratio and CFTR mRNA expression were observed. Results：Curcu-min could increase artery O2 pressure,decrease the AFC downward and wet-to-dry ratio. Curcumin could increase the expression of CFTR mRNA. Conculsion：Curcumin could protect the acute lung injury by APE and associated with upward of CFTR mRNA.

关 键 词：姜黄素 急性肺动脉栓塞 急性肺损伤 CFTR 

分 类 号：R730.23[医药卫生—肿瘤]