红花注射液对轻型急性脑梗死青年患者血清白细胞介素-6、10的影响  

Effects of safflor injection on serum IL-6 and IL-10 level of young patients with mild acute cerebral infarction

作　　者：骆彩珍[1] 高志琼[1] 江晋渝[2] 杨小艳[2] 汤建平[2] 罗勇[2] 

机构地区：[1]桂林医学院附属医院神经内科,桂林541001 [2]贵州航天医院神经内科,遵义563003

出　　处：《重庆医科大学学报》2014年第4期462-465,共4页Journal of Chongqing Medical University

基　　金：中国航天科工集团医疗卫生科研资助项目(编号:2010-JKBZ-010)

摘　　要：目的：观察红花注射液治疗轻型急性脑梗死青年患者的疗效及其对患者血清白细胞介素（interleukin，IL）-6和IL-10的影响。方法：选取住院的轻型急性脑梗死青年患者52例，神经功能缺损程度评分（neurological severity scores，NSS）为10-15分．年龄为35～40岁。随机分为对照组（常规治疗，27例）和治疗组（常规治疗＋红花注射液治疗20ml／d，25例）。所有患者均于入院时及治疗后第7、14天清晨抽取静脉血，以同龄健康人群为对照，采用双抗体夹心酶联免疫法检测IL-6、IL-10。结果：与治疗前比。治疗组和对照组患者治疗7d和14d后的NSS均明显降低（P=0．000）；其中，治疗第14天，治疗组的NSS低于对照组（P=0.040）。与治疗前比，对照组第7天的血清IL-6水平无变化（P=0．078），第14天的血清IL-6浓度明显降低（P=0．000）；治疗组第7天和第14天的血清IL-6水平均明显下降（P=-0．000）。治疗组第7天和第14天的血清IL-6水平均低于对照组（P=-0．042，P=0．000）。与治疗前比，对照组和治疗组第7天和第14天的血清IL-10水平均明显升高（P=0．000），且治疗组第7天和第14天的血清IL-10水平均高于对照组（P=0．001，P=0．038）。对照组IL-6／IL-10比值与NSS的变化无相关性（r=0．962，P=0．177）；治疗组IL-6／IL-10比值与NSS变化呈正相关（r=0．997，P=0．048）。结论：红花注射液的早期应用对于改善青年轻型急性脑梗死患者病情具有一定的改善作用，可能与其降低患者血清IL-6水平、升高IL-10水平，进而降低IL-6／IL-10比值有关。Objective：To observe the therapeutic effect of safflower injection on young patients with mild acute cerebral infarction and the effect of safflower injection on serum interleukin（IL）-6 and IL-10 level of these subjects. Methods：Totally 52 patients with mild acute cerebral infarction, aged 35-40 year-old with 10-15 neurological severity score （NSS） were randomly divided into control group（conventional treatment,27 cases） and treatment group（conventional treatment combined with safflower injection 20 ml per day, 25 cases）. Morning blood samples of all patients were monitored at three time points （before the treatment, on the 7th d and 14th d during the treatment） and were collected for IL-6 and IL-10 detection using a double antibody sandwich enzyme-linked immunosorbent assay. Blood samples of healthy people aged 35-40 years were also obtained as controls. Results：NSS of control group and treatment group on the 7th d and 14th d were all significantly decreased compared with those before treatment（all P=0.000）. On the 14th d, NSS of treatment group was lower than that of control group（P=-0.040）. Comparing with that before treatment,serum IL-6 level of control group was significantly decreased on the 14th d（P=0.000） but unchanged on the 7th d（P=0.078）. Serum IL-6 levels of treatment group were markedly decreased on the 7th d and 14th d compared with those before treatment（all P=0.000） and control group respectively （P=0.042,P=0.000）. Serum IL-10 levels of control group and treatment group were significantly increased after treating for 7 d and 14 d compared with those before treatment（P=0.000）. On the 7th d and 14th d,serum IL-10 level was higher in treatment group than in control group（P=0.001 ,P=0.038）. Positive correlation was observed between IL-6/IL-10 value and NSS in treatment group （r=0.997, P=-0.048）, but not in control group （r=0.962, P=0.177）. Conclusions： Early application of safflower injection is benefit for young patients with mild ac

关 键 词：红花注射液 青年患者 轻型急性脑梗死 白细胞介素-6 白细胞介素-10 

分 类 号：R969[医药卫生—药理学]