非复制型痘苗病毒的生物学性状研究进展  

Research Progress of Biological Characteristics of Non- Replicating Vaccinia Viruses

作　　者：庞聪[1] 田厚文[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所病毒病应急技术中心,北京102206

出　　处：《生物技术通讯》2014年第3期415-420,共6页Letters in Biotechnology

摘　　要：痘病毒被广泛用于针对多种感染性疾病和癌症的疫苗研究,而非复制型痘苗病毒的发展又进一步提高了其安全性。来源于中国天花疫苗株的复制缺陷型痘苗病毒天坛株(NTV)正是一株非复制型痘苗病毒。为了促进未来NTV作为疫苗候选株在临床中的应用,我们对NTV与另外2株非复制型痘苗病毒,即改良痘苗病毒安卡拉株(MVA)和NYVAC的生物学性状做简要综述,主要讨论了它们的基因组结构、体外生长特性、病毒复制和形态发生、组织中的病毒分布和病毒-宿主细胞间的相互作用。Poxviruses have been studied extensively as vaccines against many infectious diseases and cancer, the safety of which have been enhanced through the development of non-replicating vaccinia viruses, like replication-defective vaccinia virus Tiantan（NTV）, derived from a Chinese smallpox vaccine strain. To promote the use of NTV as a vaccine candidate in clinical application in the future, here we provided a review of the biological characteristics of NTV and another two non-replicating vaccinia viruses, modified vaccinia Ankara （MVA） and NYVAC. In this article we mainly discussed their genomic organization, growth characteristics in vitro, virus replication and morphogenesis, virus distribution in tissues and virus-host cell interactions.

关 键 词：痘苗病毒天坛株 改良痘苗病毒安卡拉株 NYVAC 复制缺陷 痘病毒载体 疫苗 

分 类 号：R392.1[医药卫生—免疫学]