西咪替丁调节阻塞性黄疸大鼠红细胞免疫功能及IL-2的实验研究  

IMMUNOMODULATING EFFECTS OF CIMETIDINE ON THE RED CELL IMMUNE FUNCTION AND INTERLEUKIN-2 IN RATS WITH OBSTRUCTIVE JAUNDICE

作　　者：丁佑铭[1] 王卫星[1] 严际慎[1] 王竹平[1] 

机构地区：[1]湖北医科大学附属第一医院普外科,武汉430060

出　　处：《中国普外基础与临床杂志》2001年第2期67-68,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　探讨西咪替丁对阻塞性黄疸大鼠红细胞免疫功能及白细胞介素 2 (IL 2 )的影响。方法　将SD大鼠60只随机均分成胆总管结扎切断 (BDL)组、西咪替丁治疗 (BDLC)组和假手术对照组 3组。分别采用红细胞酵母菌花环法和放免分析法测定红细胞免疫功能及IL 2水平。结果　BDL组大鼠红细胞C3b受体花环率 (RBC C3bRR )、红细胞免疫复合物花环率 (RICR)和红细胞C3b受体花环促进率 (RFER)均显著降低 ,红细胞C3b受体花环抑制率 (RFIR)显著升高 ,IL 2水平降低 ;BDLC组大鼠RBC C3bRR、RICR、RFER及IL 2水平明显增高 ,而RFIR明显降低。结论　西咪替丁有助于改善阻塞性黄疸大鼠红细胞免疫功能及提高IL 2水平。Objective To investigate the effects of cimetidine on the red cell immune function and interleukin-2(IL-2) in rats with obstructive jaundice. Methods Sixty SD rats were divided into bile duct ligation(BDL) group, cimetidine therapy (BDLC) group and sham operation(SO) group respectively. The red cell immue function and serum IL-2 level were determined with the red cell yeast-rosttes test and radioimmunoassay respectively. Results The red blood cell C 3b receptor rosette rate(RBC-C 3bRR), the red blood cell immune complex rosette rate(RICR), the red blood cell C 3b receptor rosette-forming excited rate(RFER) and serum IL-2 level were significantly lower in BDL group as compared with SO group, the red blood cell C 3b receptor rosette-forming inhibitory rate(RFIR) in BDL group was higher than that of SO group. After 7 days' cimetidine therapy RBC-C 3bRR, RICR, RFER and IL-2 became higher than those of BDL group, but RFIR was lower than that of BDL group. Conclusion Supplemental cimetidine can significantly enhance the impaired red cell immune function and IL-2 production in rats with obstructive jaundice.

关 键 词：西咪替丁 阻塞性黄疸 红细胞免疫 白细胞介素2 大鼠 

分 类 号：R965[医药卫生—药理学]