松龄血脉康联合降压药治疗肝阳亢进型老年原发性高血压的临床观察  

Clinical Observation of Songling Xuemaikang Combined with Anti-hypertensive Agents in the Treatment of Elderly Patients with Essential Hypertension of Liver Yang Heperactivity Pattern

作　　者：苟连平[1] 刘世平[2] 刘长萍[3] 

机构地区：[1]川北医学院附属医院心内科,四川南充637000 [2]川北医学院附属医院急诊科,四川南充637000 [3]彭州市人民医院内科,四川彭州611933

出　　处：《中国药房》2014年第24期2269-2271,共3页China Pharmacy

摘　　要：目的:观察松龄血脉康联合降压药治疗肝阳亢进型老年原发性高血压的临床疗效和安全性。方法:260例肝阳亢进型老年原发性高血压患者按随机数字表法均分为对照组和干预组。对照组患者口服苯磺酸氨氯地平5 mg,qd(视患者血压改善情况,可每半月增加1次苯磺酸氨氯地平剂量,每次增加2.5 mg,增加至10 mg时为最大剂量),并口服氢氯噻嗪25 mg,qd;干预组患者在对照组治疗的基础上口服松龄血脉康1.5 g,tid。两组患者疗程均为1年。观察两组患者的临床疗效,治疗前后左心室质量(LVM)、左心室质量指数(LVMI)、Q-T离散度(Q-Td)、校正的Q-T离散度(Q-Tcd)、收缩压(SBP)、舒张压(DBP)、清晨血压增高值(IMBP)及不良反应发生情况。结果:干预组患者总有效率显著高于对照组患者,两组比较差异有统计学意义(P<0.05)。治疗前两组患者LVM、LVMI、Q-Td、Q-Tcd、SBP、DBP、IMBP(SBP)、IMBP(DBP)比较,差异均无统计学意义(P>0.05);治疗后两组患者LVM、LVMI、Q-Td、Q-Tcd、SBP、IMBP(SBP)、IMBP(DBP)均显著低于同组治疗前,且除DBP外,干预组其他指标均显著低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:松龄血脉康联合降压药治疗肝阳亢进型老年原发性高血压疗效显著,安全性较好。OBJECTIVE： To observe therapeutic efficacy and safety of Songling xuemaikang combined with anti-hypertensive agents in the treatment of elderly patients with essential hypertension of liver yang heperactivity pattern. METHODS： 260 elderly patients with essential hypertension of liver yang heperactivity pattern were randomly divided into control group and intervention group. Control group was given amlodipine besylate 5 mg, qd, dihydrochlorothiazide 25 mg, qd, adding amlodipine besylate 2.5 mg once every 15 days according to the improvement of blood pressure, maximal dose of 10 mg. Intervention group was additional- ly given Songling xuemaikang 1.5 g, rid on the basis of control group. Treatment course of 2 groups lasted for 12 months. Clinical efficacies of 2 groups were observed. LVM, LVMI, Q-Td, Q-Tcd, DBP, SBP, IMBP and ADR were also observed before and after treatment. RESULTS： Total effective rate of intervention group was significantly higher than that of control group; there was statistical significance （P〈0.05） ; there was no statistical significance in LVM, LVMI, Q-Td, Q-Tcd, SBP, DBP and IMBP before treatment （P〉0.05）. LVM, LVMI, Q-Td, Q-Tcd, SBP and IMBP of 2 groups after treatment were significantly lower than be- fore; those index of intervention group were lower than control group except DBP; there was staitsical significance （P〈0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Songling xuemaikang combined with anti-hypertensive agents is effective and safe for elderly patients with essential hypertension of liver yang heperactivity pattern.

关 键 词：松龄血脉康 老年原发性高血压 肝阳亢进型 苯磺酸氨氯地平 氢氯噻嗪 

分 类 号：R544.1[医药卫生—心血管疾病]