姜黄素自微乳在Beagle犬体内的药动学分析  

Pharmacokinetics of Curcumin Self-microemulsions in Beagle Dogs

作　　者：石磊 王汝上 

机构地区：[1]江西省医药学校,南昌330200 [2]广州康臣药物研究有限公司,广州510530

出　　处：《中国实验方剂学杂志》2014年第12期133-135,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江苏省中医药领军人才项目(2006)

摘　　要：目的：考察姜黄素白微乳在Beagle犬体内的血药浓度经时过程并评价其相对生物利用度。方法：Beagle犬分别单剂量给予姜黄素自微乳及其混悬液，通过HPLC测定血浆中姜黄素的质量浓度，流动相甲醇（A）-水（B）梯度洗脱（0-15min，30％～70％A；15～30min，70％～90％A），检测波长425nm，采用DAS2．1．1程序拟合药-时曲线，计算药代动力学参数及生物利用度。结果：姜黄素自微乳与混悬液的药代动力学参数t_max分别为3．0，2．0h，C_max分别为3304．3，1873．6ng·L-1，AUC_0.24依次为6537．5，2973．2ng·h·L-1，姜黄素自微乳相对于混悬液的生物利用度达219．88％。结论：姜黄素自微乳可显著提高药物在Beagle犬体内的生物利用度。Objective： To investigate plasma concentration-time process of curcumin self-microemulsions in Beagle dogs and evaluate its relative bioavailability. Method： Beagle dogs were given a single dose of curcumin microemulsions and its suspensions, HPLC was adopted to determine the concentration of curcumin in plasma with mobile phase of methanol （A） -water （B） （0-15 min, 30%-70% A; 15-30 min, 70%-90% A） for gradient elution and detection wavelength at 425 nm, pharmacokinetics parameters and bioavailability were calculated by DAS 2. 1.1 programs. Result： T_max of curcumin self-microemulsions and suspensions were 3.0 and 2.0 h, C_max were 3 304.3 and 1 873.6 ng·L-1 , AUCo_24h were 6 537.5 and 2 973.2 ng ·h ·L-1 of curcumin self-microemulsions relative to curcumin suspensions were 219.88% microemulsions could significantly improve bioavailability in Beagle dogs. , respectively. Conclusion ： Bioavailability Curcumin self-microemulsions could significantly improve bioavailability in Beagle dogs.

关 键 词：姜黄素 自微乳 BEAGLE犬 药代动力学 生物利用度 混悬液 

分 类 号：R283.6[医药卫生—中药学]