小儿肺咳合剂治疗儿童咳嗽变异性哮喘60例  

Xiaoer Feike Mixture in Treating Children Cough Variant Asthma with 60 Cases

作　　者：荣潇[1] 李琼[2] 杜晓宁[2] 张戬[2] 

机构地区：[1]石家庄市第一医院,石家庄050011 [2]哈励逊国际和平医院,河北衡水053000

出　　处：《中国实验方剂学杂志》2014年第12期234-237,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：衡水市科技局科学技术进步项目(11011z)

摘　　要：目的：探讨小儿肺咳合剂治疗儿童咳嗽变异性哮喘（CVA）的疗效及对肺功能、血清总IgE和外周血嗜酸性粒细胞（EOS）的影响。方法：将120例CVA随机按数字法分为对照组和观察组各60例。对照组采用孟鲁司特钠咀嚼片，〈6岁4mg，〉6岁5mg，1次／d，夜间睡前服用。硫酸特布他林片，3～6岁，1．25mg／次，3次／d，〉6岁，2．5mg／次，3次／d。观察组在对照组治疗的基础上加服小儿肺咳合剂，1剂／d。两组疗程均为28d。记录治疗前后咳嗽频率及咳嗽强度等症状、体征积分，观察咳嗽减轻和消失时间；进行治疗前后肺功能测定（〉8岁患者）；检测治疗前后血清总免疫球蛋白E（1gE）和外周血嗜酸性粒细胞（EOS）。结果：观察组疾病综合疗效总有效率为95％，优于对照组的80％（P〈0．05）；观察组咳嗽频率、咳嗽程度、次证总分及症状体征总分均低于对照组（P〈0．01）；观察组咳嗽减轻时间及咳嗽消失时间均短于对照组（P〈0．01）；两组治疗后肺功能指标：肺活量的呼气流速（FEF25％，FEF50％和FEF75％）均较治疗前提高，观察组提高更为显著（P〈0．01）；治疗后两组血清总IgE和EOS均较治疗前降低，观察组血清总IgE和EOS低于对照组（P〈0．01）。结论：小儿肺咳合剂能抗变应性炎症，降低气道的高反应性，治疗儿童咳嗽变异性哮喘疗效显著。Objective： Observe curative effect of Xiaoer asthma （CVA） and influence to pulmonary function, serum total Feike mixture in treating children cough variant immune globulin E （IgE） and peripheral blood eosinophil （EOS）. Method： One hundred and twenty patients with CVA were randomly divided into control group （60 cases） and observation group （60 eases） by random number table. Patients in control group received montelukast sodium chewable tables, 4 mg/time （children were less than 6 years old） , 5 mg/time （children were more than 6 years old） , 1 time/day, taken orally before sleeping, and terbutaline sulfate tablets, 1.25 mg/ time （children were at 3-6 years old） , 3 times/day, and 2.5 mg/time （children were more than 6 years old） , 3 times/day. Based on the therapy of control group, patients in observation group added Xiaoer Feike mixture, l dose/day. Course of treatment in two groups were 28 days. Before and after treatment, frequency of cough, intensity of cough, integral of signs and the time of relief and disappearance of cough were recorded. Pulmonary functions of patients more than 6 years old were measured, and total immune globulin E （ IgE ） and peripheral blood eosinophil （EOS） were detected. Result： The total effective rate of illness curative effect in the observation group was 95% superior to 80% in the control group （P 〈0.05）. Frequency of cough, degree of cough and totalscores of minor symptoms, symptoms and signs in the observation group were lower than those in the control group （P 〈0. 01 ）. The time of relief and disappearance of cough in the observation group were less than those in the control group （P 〈 0.01 ）. Compared with the time before treatment, vital capacity breath flow volume （FEF25% , FEFS0% and FEF75% ） of pulmonary function indexes in both groups increased, and the increasing in the observation group was more significant than in the control group （P 〈0.01）. After treatment, serum total IgE and EOS in both

关 键 词：咳嗽变异性哮喘 小儿肺咳合剂 肺功能 血清总IGE 外周血嗜酸性粒细胞 

分 类 号：R287[医药卫生—中药学]