离子液体萃取-荧光分光光度法测定甲磺酸多沙唑嗪  

Determination of Doxazosin Mesylate by Ionic liquids Extraction-Fluorescence Spectrophotometry

作　　者：陈彩萍[1] 陈慧娴[1] 畅雅芬 杜黎明[1] 牛庆卫 

机构地区：[1]山西师范大学分析测试中心,山西临汾041004

出　　处：《分析科学学报》2014年第3期381-384,共4页Journal of Analytical Science

基　　金：教育部高等学校博士学科点专项基金(No.20091404110001)

摘　　要：选择水溶性的离子液体1-辛基-3-甲基咪唑四氟硼酸盐（[OMIM]BF4）对甲磺酸多沙唑嗪进行萃取，利用荧光分光光度法测定甲磺酸多沙唑嗪的含量。方法线性范围为0．01～172ng／mL，检测限为0．0032ng／mL。该方法可运用于药物制剂及尿样中甲磺酸多沙唑嗪的测定，其回收率分别为99．6％和95．8％～99．7％。Ionic liquid is environmentally friendly as an alternative to organic solvents during extraction, which has some unique physical and chemical properties. This paper studies the extraction of the doxazosin mesylate in aqueous phase using 1-octyl-3-methylimidazolium tetrafluoroborate （[Omim]BF4） as extraction solvent. The method is simple, rapid, inexpensive, sensitivity and reliable. Under optimized conditions, the fluorescence intensity of doxazosin mesylate is proportional to the concentration in the range of 0.01 ng/mL-172 ng/ mL,and the detection limit is 0.0032 ng/mL. Therefore,an efficient fluorescence spectrophotometry method for the determination of doxazosin mesylate is established.

关 键 词：甲磺酸多沙唑嗪 离子液体 微萃取 荧光分光光度法 

分 类 号：O657.39[理学—分析化学]