头孢米诺钠的电化学行为研究及含量检测  

Electrochemical Determination of Cefminox Sodium by Single Sweep Polarography

作　　者：董丽丽[1] 李敏[1] 胡章记[1] 镡彩霞 李海超[1] 吴远远[1] 

机构地区：[1]邢台学院生物化学系,河北邢台054001

出　　处：《分析科学学报》2014年第3期409-412,共4页Journal of Analytical Science

摘　　要：结合多种电化学手段研究了头孢米诺钠的电化学行为。在pH=1．35的磷酸底液中头孢米诺钠产生不可逆吸附还原波，峰电位为-0．748V（vs．SCE），有1个电子与1个质子参与电板过程。基于电极反应机理，建立了单扫描极谱法测定头孢米诺钠的新方法。极谱峰电流与头孢米诺钠的浓度在10～650μg／mL范围内有良好的线性关系（r=0．9995），检测限（S／N=3）为2μg／mL。将该法分别应用于注射针剂、模拟血浆、尿样的测定，结果满意。The voltammetric behavior of cefminox sodium has been studied, and an irreversible adsorped reduction peak at the potential --0. 748 V（vs. SCE） involving one electron and one proton was obtained in the medium of phosphate buffer（pH= 1.35）. Based on the mechanism of electrode reduction, single- sweeping polarography was developed to the determination of eefminox sodium. Linear relationship between peak current（Ie） and concentration of cefminox sodium was obtained in the range of 10-650μg/ mL. Detection limit of the method was found to be 2 μg/mL（S/N=3）. The proposed method was used in the determination of cefminox sodium in injections,blood and urine samples with satisfactory results.

关 键 词：头孢米诺钠 单扫描极谱法 针剂 血浆 尿样 

分 类 号：O657.1[理学—分析化学]