DNA自组装技术及其在电离辐射检测中的应用  

DNA self-assembly technology and its application in ionizing radiation detection

作　　者：张宏陆[1] 李凡[1] 柳华杰[1] 晁洁[1] 

机构地区：[1]中国科学院上海应用物理研究所,嘉定园区上海201800

出　　处：《辐射研究与辐射工艺学报》2014年第3期1-10,共10页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金项目(21105110;21103219)资助

摘　　要：电离辐射能够造成DNA分子的损伤(如改变碱基、链断裂和分子交联等)、抑制DNA合成和增强DNA分解等,进而会影响DNA自组装技术构建的纳米结构构型的变化,利用这一性质可用于电离辐射的检测。本文主要介绍了DNA自组装技术在结构和动态两方面的最新进展,并对DNA自组装技术在电离辐射检测中的应用,尤其是DNA拼块自组装纳米结构用于α粒子和β粒子辐照的高灵敏检测器等领域的最新进展进行了综述。Ionizing radiation can cause damage on DNA （such as physically breaking one or both of the sugar phosphate backbones, breaking the base pairs or hydrogen bonds of the DNA）, inhibit synthesis of DNA and promote degradation of DNA. These effects will further change the configuration of DNA self-assembled nanostructures, which can be applied in detection of ionizing radiation. This work reviews the developments of DNA self-assembly technology in recent years, and introduces the applications of DNA self-assembly in ionizing radiation detection, especially in detection of α and β particle radiations based on DNA tile self-assembly.

关 键 词：辐射物理与技术 DNA自组装 DNA纳米技术 电离辐射 辐射检测 

分 类 号：O653[理学—分析化学] TL84[理学—化学]