胸外科手术患者帕瑞普布钠超前镇痛效果  

Postoperative analgesic effect of parecoxib sodium preemptive analgesia on patients undergoing thoracic surgery

作　　者：辛学东[1] 孙俊枝[1] 于建设[1] 

机构地区：[1]内蒙古医科大学第一附属医院,内蒙古呼和浩特272200

出　　处：《中国医院药学杂志》2014年第11期915-918,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探讨帕瑞普布钠超前镇痛对硬膜外麻醉的胸外科手术患者术后镇痛效果的影响。方法:选取2010年6月-2013年6月在某院胸外科行择期手术的90例患者为研究对象,根据随机数字表将患者分为A组(术前20 min给予40 mg帕瑞普布钠镇静麻醉)30例,B组(手术缝合时给予40 mg帕瑞普布钠镇静麻醉)30例以及空白对照组30例。分别于术后3,6,12,24,48 h采用视觉模拟评分法(VAS)对3组患者镇痛效果进行评分。结果:A组、B组术后3,6,12,24 h VAS评分均显著低于C组,且A组术后3,6 h VAS评分低于B组(P<0.05)。A组、B组术后12,24 h舒芬太尼用量均显著低于C组,且A组低于B组(P<0.05)。A组、B组恶心呕吐、躁动、呼吸抑制发生率均显著低于C组,A组恶心呕吐低于B组(P<0.05)。结论:对胸外科手术患者应用帕瑞普布钠超前镇痛能有效降低患者麻醉苏醒期躁动的发生,提高患者镇静镇痛效果,减少患者术后PICA舒芬太尼使用量。OBJECTIVE To investigate the postoperative analgesic effect of pareeoxih sodium preemptive analgesia on pa- tients undergoing thoracic surgery. METHODS 90 patients undergoing elective surgery were divided into group A （given 40 mg parecoxib sodium 20 rain before surgery） 30 cases , group B （given 40 mg parecoxib sodium during surgical suture ） 30 cases and blank control group 30 cases from June 2010 to June 2013 in our hospital routine thoracic surgery. The postoperative anal-gesic effects of three groups were analyzed with visual analog scale （VAS） 3, 6, 12, 24,48 h after thoracic surgery, respective- ly. RESULTN The VAS scores of group A and group B were lower than that of group C 3, 6, 12, 24 h after operation, the VAS score of group A was lower than that of group B 3, 6 h after operation （P〈0. 05）. The sufentanil dosages of group A and group B were lower than that of group C 12, 24 h after operation. The sufentanil dosage of group A was lower than that of group B 12, 24 h after operation （P〈0. 05）. The nausea, vomiting, restlessness and respiratory depression of group A and group B were lower than those of group C. The nausea and vomiting of group A was lower than that of group B （P%0.05）. CONCLUSION In thoracic surgery patients, parecoxib sodium preemptive analgesia can effectively reduce restlessness occur- rence in anesthesia recovery period, improve patient＇s sedative and analgesic effects, and reduce postoperative PICA sufentanil consumption.

关 键 词：帕瑞普布钠 镇痛 胸外科手术 

分 类 号：R971.2[医药卫生—药品]