辛可尼丁和L-脯氨酸协同催化亚胺的立体选择性异构化的研究  

Stereoselectivity Isomerization of Imines Catalyzed by Cinchonidine and L-proline

作　　者：杨伟[1] 李莉[2] 杨科芳[1] 郑战江[1] 徐利文[1] 

机构地区：[1]杭州师范大学有机硅化学及材料技术教育部重点实验室,浙江杭州311121 [2]杭州师范大学材料与化学化工学院,浙江杭州310036

出　　处：《杭州师范大学学报（自然科学版）》2014年第3期235-239,共5页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：浙江省自然科学基金项目(ZPNSFC;LQ12B02004)

摘　　要：研究了利用辛可尼丁和L-脯氨酸复合催化体系促进含三氟甲基芳香亚胺1的不对称异构化反应,并详细考察了不同种类的有机催化剂、溶剂以及添加剂对反应产率与选择性的影响.结果表明,当以四氢呋喃作溶剂,2-环己烯-1-酮为添加剂时,反应的分离产率与立体选择性最好,可以达到64%的产率,68%的ee值.In this work ,it is found that the composite catalyst system of cinchonidine and L‐proline can promote the asymmetric isomerization reaction containing trifluoromethyl aromatic imine .The paper investigates the effects of different organocatalysts ,solvents and additives on the reaction yield and selectivity .The results show that the reaction has optimal separation yield and stereoselectivity with tetrahydrofuran as the solvent and 2‐cyclohexene‐1‐ketone as the additive ,the yield can up to 64% and ee value can up to 68% .

关 键 词：亚胺异构化 金鸡纳碱 手性 希夫碱 不对称催化 

分 类 号：O626.5[理学—有机化学]