蛋白酪氨酸磷酸酶-1和表皮生长因子受体在尖锐湿疣组织中的表达及意义  

Expression and significance of protein tyrosine phosphatase-1 and epidermal growth factor receptor in condyloma acuminatum

作　　者：薛亚东[1] 蔡丽敏[1] 刘静[1] 王燕华[1] 周毅成[1] 郑淑云[1] 

机构地区：[1]哈尔滨医科大学附属一院皮肤科,黑龙江哈尔滨150086

出　　处：《海南医学院学报》2014年第7期913-915,共3页Journal of Hainan Medical University

基　　金：黑龙江省教育厅科学技术研究项目(12511180)~~

摘　　要：目的：探讨蛋白酪氨酸磷酸酶-1和表皮生长因子受体在尖锐湿疣组织中的表达及临床意义。方法：随机选择2013年1-12月我院收治的24例尖锐湿疣患者作为观察组，同期正常人群20例作为对照组，应用免疫组化方法检测尖锐湿疣组织和正常人包皮组织中蛋白酪氨酸磷酸酶-1和表皮生长因子受体的表达情况。结果：尖锐湿疣组织中蛋白酪氨酸磷酸酶-1阳性表达率为83．33％，主要在棘细胞层和颗粒层表达；正常包皮组织蛋白酪氨酸磷酸酶-1阳性表达率为95．00％，染色以基底层和棘层下部胞膜，组间差异无统计学意义（P〉0．05）。而尖锐湿疣中蛋白酪氨酸磷酸酶-1表达量低于对照组，差异有统计学意义（P〈o．05）；表皮生长因子受体均有表达，其表达量显著高于对照组，差异有统计学意义（P〈0．05）；观察组蛋白酪氨酸磷酸酶-1阳性表达率为83．33％，表皮生长因子受体阳性表达率为100．00％，差异有统计学意义（P〈0．05）；两者在尖锐湿疣组织中的表达呈负相关（r=-0．72，P〈0．05）。结论：蛋白酪氨酸磷酸酶-1和表皮生长因子受体在尖锐湿疣组织中表达异常，且与尖锐湿疣细胞过度增殖密切相关。Objective： To investigate the protein tyrosine phosphatase -1 and expression of epider- mal growth factor receptor in condyloma acuminatum and its clinical significance. Method. A total of 24 cases of condyloma acuminatum were randomly selected from 2013 January to 2013 December were select- ed as study object, fwhile 20 normal people as a control. Expression of protein tyrosine phosphatase -1 and expression of epidermal growth factor receptor was detected by immunohistochemical assay. Results. In condyloma acuminata tissues protein tyrosine phosphatase positive expression rate of-1 was 83. 33%,which was mainly expressed in the prickle cell layer and granular layer. In normal foreskin tissue protein tyrosine phosphatase positive expression rate of -1 was 95.00%, staining in basal and spinous layers lower cell membrane; the differences between groups were not statistically significant （P〉0.05）. The protein tyrosine phosphatase in condyloma acuminatum -1 expression was significantly lower than that of the con- trol group （P〈0.05）; epidermal growth factor receptor expression was significantly higher than that in the control group （P〈0.05）; protein tyrosine phosphatase -1 in the observed group positive rate was 83.33%, epidermal growth factor receptor in the observation group the positive expression rate of 100.00% ,the difference was significant （P〈0.05）. They were negatively correlated with condyloma acu- minata tissues （r=0.72, P〈0.05）. Conclusions. Protein tyrosine phosphatase-1 and epidermal growth factor receptor show abnormal expression in condyloma acuminata, and is closely related to with condylo- ma acuminatum excessive cell proliferation.

关 键 词：蛋白酪氨酸磷酸酶-1 表皮生长因子受体 尖锐湿疣组织 正常包皮组织 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]