头孢克肟在小儿急性细菌性肠炎中的疗效及对炎性指标的影响  

Effects of cefixime on acute bacterial enteritis in children and its influence on inflammatory indexes

作　　者：张静 洪岩[2] 段武琼[3] 

机构地区：[1]陕西省安康市汉滨区第三人民医院儿一科,陕西安康725018 [2]陕西省安康市中医院儿科 [3]陕西省安康市中心医院儿科,陕西安康725000

出　　处：《海南医学院学报》2014年第7期970-972,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210147)~~

摘　　要：目的:观察头孢克肟在小儿急性细菌性肠炎中的疗效及对炎性指标的影响。方法:选取于本院进行治疗的90例急性细菌性肠炎患儿为研究对象,将其随机分为对照组(头孢克洛组)45例和观察组(头孢克肟组)45例,然后将两组中发热与未发热者的总有效率及治疗前、治疗后不同时间的血清白介素-8(IL-8)、降钙素原(PCT)及肿瘤坏死因子-α(TNF-α)含量和阳性率进行比较。结果:观察组中发热与未发热者的总有效率均分别高于对照组,治疗后不同时间的血清IL-8、PCT及TNF-α含量和阳性率均低于对照组及观察组治疗前,差异具有统计学意义(P<0.05)。结论:头孢克肟在小儿急性细菌性肠炎中的综合疗效较好,且其对患儿的血清炎性指标也有较佳的控制作用。Objective, To observe the effect of cefixime on acute bacterial enteritis in children and its influence on inflammatory indexes. Methods.A total of 90 children with acute bacterial enteritis treated in our hospital were selected and randomly divided into control group（cefaclor group, n=45 cases） and ob servation group（cefixime group, n=45 cases）, then the total effective rates of patients with fever and without fever, serum content and positive rate of IL-8,PCT and TNF-α before and after the treatment were compared. Results. The total effective rates of patients with fever or without fever in the observation group were higher than those of control group. After treatment, serum content and positive rate of IL-8, PCT and TNF-α were all lower than those of control group and those parameters of observation group were al-soe lower than that before the treatment （P〈0.05）. Conclusion. The comprehensive effect of cefixime in the treatment of children with acute bacterial enteritis is good, and it can control the serum inflammatoryindexes effectively.

关 键 词：头孢克肟 小儿急性细菌性肠炎 炎性指标 

分 类 号：R725.7[医药卫生—儿科]