几丁糖酯抗动脉粥样硬化作用研究  

Studies on the antiatherosclerotic effects of chitosan ester

作　　者：丁华[1] 祝清芬[1] 徐鲁源[1] 吴葆杰[1] 李英霞[2] 吕志华[2] 

机构地区：[1]山东医科大学基础医学院药理学教研室,济南250012 [2]青岛海洋大学海洋药物与食品研究所,青岛266003

出　　处：《中国海洋药物》2001年第1期12-16,27,共6页Chinese Journal of Marine Drugs

摘　　要：用高脂膳食喂养家兔建立动脉粥样硬化模型 ,观察几丁糖酯对脂质代谢及主动脉斑块形成的影响。结果表明 ,几丁糖酯可以降低家兔血清中甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (L DL- C)及丙二醛 (MDA)含量 ,升高高密度脂蛋白胆固醇 (HDL- C) ,减轻肝脏脂肪样变 ,减轻主动脉斑块形成程度 ;在体外培养牛主动脉平滑肌细胞 ,观察几丁糖酯对细胞增殖的影响。结果表明 ,几丁糖酯可抑制血管平滑肌细胞增殖。透射电镜观察 ,给药组细胞呈现收缩型的形态学特征 。The in vivo antiatherosclerotic effect of chitosan ester was evaluated in diet induced hyperlipidemia rabbits. The results showed that comparison with hyperlipidemia model, chitosan ester decreased TC, TG, LDL C and MDA, but increased HDL C markedly. The formation of fatty liver and atherosclerotic plaque was decreased in chitosan ester groups. In another study the antiproliferative effect of chitosan ester on cultured bovine aortic smooth muscle cells (BASMCs) were observed. Chitosan ester was found to inhibit the proliferation of BASMCs in vitro, and it could also keep the cells in a contractile phenotype.

关 键 词：几丁糖酯 壳聚糖 高脂血症 血管平滑肌细胞 动脉粥样硬化 动物模型 

分 类 号：R543.505[医药卫生—心血管疾病] R972.6[医药卫生—内科学]