N-芳基哌嗪的合成工艺改进  

Improvement on the Synthetic Process of N-Aryl Piperazines

作　　者：刘宁[1] 陈锦春[1] 

机构地区：[1]烟台大学化学化工学院,山东烟台264005

出　　处：《广州化工》2014年第11期66-67,共2页GuangZhou Chemical Industry

基　　金：烟台大学博士科研启动基金项目(HY07B30)

摘　　要：以二氯乙胺盐酸盐和取代苯胺为原料,正丁醇做溶剂,在无碱的条件下回流以较高产率合成了取代芳基哌嗪,其结构经1H-NMR确认无误。由于反应产物能直接从反应体系中结晶析出且滤液可重复套用多次,使得该合成新方法适合于工业化规模生产。与文献报道方法相比较,新工艺简化了操作步骤、降低了产物的分离难度、提高了收率和产品纯度。By using N,N-bis（2-chloroethyl）amine hydrochloride and substituted aniline as initial material , n-butyl alcohol as the solvent , refluxing in the absence of base to convert to corresponding N -aryl piperazines in high yield.The structure was confirmed by 1 H-NMR.The product can crystallize directly from the system and the filtrate can be used several times so that the new synthetic method was applicable in the industrial scale production .Compared to the reported method , the new process simplified the operation steps , reduced the difficulty of the product separation and improved the yield and purity of the product.

关 键 词：N-芳基哌嗪 二氯乙胺盐酸盐 取代苯胺 合成工艺 

分 类 号：TQ465.9[化学工程—制药化工]